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利赛膦酸钠

利赛膦酸钠用途

Risedronate钠是双磷酸盐,能抑制破骨细胞介导的骨吸收。

利赛膦酸钠名称

[ CAS 号 ]:
115436-72-1

[ 中文名 ]:
利赛膦酸钠

[ 英文名 ]:
Sodium risedronate

[中文别名 ]:

[英文别名 ]:

T6NJ C1XQPQQO&PQQO &&Mono Na salt
Actonel
Risedronic acid monosodium salt
Benet
MFCD01706268
Sodium risedronate
Risedronic acid sodium salt
Optinate
Risedronate sodium

利赛膦酸钠生物活性

[ 描述 ]:

Risedronate钠是双磷酸盐,能抑制破骨细胞介导的骨吸收。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[参考文献]

[1]. Giljevic Z, et al. Treatment of osteoporosis by risedronate-- speed, efficacy and safety. Reumatizam. 2006;53(2):66-71.

[2]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

[相关活性小分子]

利赛膦酸钠物理化学性质

[ 沸点 ]:
692.3ºC at 760 mmHg

[ 熔点 ]:
252-262°C

[ 分子式 ]:
C₇H₁₀NNaO₇P₂

[ 分子量 ]:
305.094

[ 闪点 ]:
372.5ºC

[ 精确质量 ]:
304.983032

[ PSA ]:
170.63000

[ LogP ]:
0.06380

[ 外观性状 ]:
细白色至灰白色结晶粉末

[ 蒸汽压 ]:
4.03E-20mmHg at 25°C

[ 储存条件 ]:
Store at RT

利赛膦酸钠MSDS

详细MSDS(安全技术说明书)

利赛膦酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ8567500

CHEMICAL NAME :: Phosphonic acid, (1-hydroxy-2-(3-pyridinyl)ethylidene)bis-, monosodium salt

CAS REGISTRY NUMBER :: 115436-72-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H10-N-O7-P2.Na

MOLECULAR WEIGHT :: 305.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1800 ug/kg/3D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - iritis

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 341,436,1993

利赛膦酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SZ8567500

利赛膦酸钠文献

Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats.

Arch. Pharm. Res. 37(12) , 1560-9, (2014)

Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailabil...

Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.

Biochim. Biophys. Acta 1841(7) , 977-86, (2014)

2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cho...

Risedronate increases osteoblastic differentiation and function through connexin43.

Biochem. Biophys. Res. Commun. 432(1) , 152-6, (2013)

Bisphosphonates are potent antiresorptive drugs which have antifracture efficacy by reducing bone turnover rate and increasing bone mineral density. In addition to inhibiting osteoclast function, bisp...

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