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角鲨烷

角鲨烷用途

Squalane,可在某些鱼油 (尤其是鲨鱼肝油) 和某些植物油中发现,是 Squalene 的饱和衍生物。Squalane 具有抗癌,抗氧化效果。Squalane 常用作皮肤保湿和润肤剂。

角鲨烷名称

[ CAS 号 ]:
111-01-3

[ 中文名 ]:
角鲨烷

[ 英文名 ]:
Squalane

[中文别名 ]:

[英文别名 ]:

Squalane
Robane
Cosbiol
Perhydrosqualene
2,6,10,15,19,23-hexamethylteracosane
Spinacane
2,6,10,15,19,23-Hexamethyltetracosane
Dodecahydrosqualene
Vitabiosol
MFCD00008953

角鲨烷生物活性

[ 描述 ]:

Squalane,可在某些鱼油 (尤其是鲨鱼肝油) 和某些植物油中发现,是 Squalene 的饱和衍生物。Squalane 具有抗癌,抗氧化效果。Squalane 常用作皮肤保湿和润肤剂。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

角鲨烷在保健和制药工业中显示出巨大的潜力。角鲨烷具有抗癌、抗氧化、载药、解毒、皮肤保湿和润肤剂活性,在动物模型和体外环境中都有报道[1]。

[参考文献]

[1]. Kim SK, et al. Biological importance and applications of squalene and squalane. Adv Food Nutr Res. 2012;65:223-33.

角鲨烷物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
470.3±0.0 °C at 760 mmHg

[ 熔点 ]:
−38 °C(lit.)

[ 分子式 ]:
C₃₀H₆₂

[ 分子量 ]:
422.813

[ 闪点 ]:
217.8±0.0 °C

[ 精确质量 ]:
422.485138

[ LogP ]:
15.59

[ 外观性状 ]:
黏的无色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.448

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

角鲨烷MSDS

角鲨烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XB6070000

CHEMICAL NAME :: Tetracosane, 2,6,10,15,19,23-hexamethyl-

CAS REGISTRY NUMBER :: 111-01-3

BEILSTEIN REFERENCE NO. :: 0776019

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C30-H62

MOLECULAR WEIGHT :: 422.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84063 No. of Facilities: 109 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 20918 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84063 No. of Facilities: 1980 (estimated) No. of Industries: 11 No. of Occupations: 32 No. of Employees: 149812 (estimated) No. of Female Employees: 126648 (estimated)

角鲨烷安全信息

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XB6070000

[ 海关编码 ]:
2901100000

角鲨烷合成路线

角鲨烷上下游产品

角鲨烷上游产品

角鲨烷下游产品

角鲨烷制备

1.角鲨烷由角鲨烯氢化制得。角鲨烯存在于蓝鲸和鲨鱼肝中,可采用提取的方法获得,再经精制得角鲨烯.

角鲨烷海关

[ 海关编码 ]: 2901100000

[ 中文概述 ]:
2901100000 饱和无环烃。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:2.0%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 用作气体燃料的应报明包装容器容积, 散装货物应报明

[ Summary ]:
2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

角鲨烷文献

Biological importance and applications of squalene and squalane.

Adv. Food Nutr. Res. 65 , 223-33, (2012)

Squalene is a polyunsaturated hydrocarbon with a formula of C₃₀H₅₀. Squalene can be found in certain fish oils, especially shark liver oil, in high amounts and some vegetable oils in relatively smalle...

How membrane permeation is affected by donor delivery solvent.

Phys. Chem. Chem. Phys. 14(44) , 15525-38, (2012)

We investigate theoretically and experimentally how the rate and extent of membrane permeation is affected by switching the donor delivery solvent from water to squalane for different permeants and me...

Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model.

J. Oleo Sci. 62(1) , 21-8, (2013)

Active oxygen has been implicated in the pathogenesis of Parkinson's disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural trit...

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角鲨烷