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毛地黄皂苷

毛地黄皂苷用途

Digitonin是从洋地黄中提取的糖苷,可通过与胆固醇分子结合来增加细胞膜的通透性,并能抑制肿瘤生长。

毛地黄皂苷名称

[ CAS 号 ]:
11024-24-1

[ 中文名 ]:
洋地黄皂苷

[ 英文名 ]:
Digitonin

[中文别名 ]:

[英文别名 ]:

MFCD00077729
DigitoninGr
galactopyranoside]
yl-(1.fwdarw.4)
EINECS 234-255-6
DIGITIN
Digitonin,Digitin
Digitonin

毛地黄皂苷生物活性

[ 描述 ]:

Digitonin是从洋地黄中提取的糖苷,可通过与胆固醇分子结合来增加细胞膜的通透性,并能抑制肿瘤生长。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 糖和糖苷

[体外研究]

Digitonin是一种通过与细胞膜中的胆固醇分子结合而增加细胞通透性的去污剂,可以增加顺铂的积累并减少体外肿瘤的生长[1]。

[体内研究]

在肝实质中,浓度具有相同的量级。使用133Xe清除技术测量,Digitonin不会改变肿瘤血流量。数字肌肽在5 mg/kg但不是25 mg/kg时增强了CBDCA的肿瘤生长迟缓效应[1]。

[参考文献]

[1]. Lindnér PG, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol. 1997;40(5):444-8.

[相关活性小分子]

毛地黄皂苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 熔点 ]:
230-240ºC

[ 分子式 ]:
C₅₆H₉₂O₂₉

[ 分子量 ]:
1229.312

[ 精确质量 ]:
1228.572388

[ PSA ]:
454.67000

[ LogP ]:
-0.62

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.660

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

毛地黄皂苷MSDS

详细MSDS(安全技术说明书)

毛地黄皂苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: IH2050050

CHEMICAL NAME :: Digitonin

CAS REGISTRY NUMBER :: 11024-24-1

BEILSTEIN REFERENCE NO. :: 0078654

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C56-H92-O29

MOLECULAR WEIGHT :: 1229.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 250 ppb

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 407,186,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83375 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83375 No. of Facilities: 104 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1495 (estimated) No. of Female Employees: 1234 (estimated)

毛地黄皂苷安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H330

[ 警示性声明 ]:
P260-P280-P284-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S22-S28-S36/37-S45

[ 危险品运输编码 ]:
UN 3462

[ WGK德国 ]:
3

[ RTECS号 ]:
IH2050050

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29389090

毛地黄皂苷文献

Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.

Virology 476 , 168-79, (2015)

Combinations of direct-acting antivirals (DAAs) against the hepatitis C virus (HCV) have the potential to revolutionize the HCV therapeutic regime. An integral component of DAA combination therapies i...

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

Toxicol. Appl. Pharmacol. 282(1) , 77-89, (2015)

The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a ...

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.

Nat. Commun. 6 , 6119, (2015)

Toll-like receptor 7 (TLR7) senses microbial-derived RNA but can also potentially respond to self-derived RNA. To prevent autoimmune responses, TLR7 is thought to localize in endolysosomes. Contrary t...

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