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1,4-丁二胺

1,4-丁二胺用途

1,4-Butanediamine 是高等植物大麦和油菜受 Cr (III) 或 Cr (VI) 胁迫引起污染的指标。1,4-Butanediamine 是 GABA 的重要来源。

1,4-丁二胺名称

[ CAS 号 ]:
110-60-1

[ 中文名 ]:
四亚甲基二胺

[ 英文名 ]:
putrescine

[中文别名 ]:

[英文别名 ]:

1,4-DIAMINOBUTAN
butane-1.4-diamine
Tetramethylenediamine
1,4-Butanediamine
1,4-butylenediamine
Putrescine, free base
Butan-1,4-diamin
Butane-1,4-diamine
putrescine
EINECS 203-782-3

1,4-丁二胺生物活性

[ 描述 ]:

1,4-Butanediamine 是高等植物大麦和油菜受 Cr (III) 或 Cr (VI) 胁迫引起污染的指标。1,4-Butanediamine 是 GABA 的重要来源。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

1,4-丁二胺(腐胺)是出生后大鼠脑室下区GABA的重要来源。来自替代途径的GABA合成使用1,4-丁二胺作为前体。

[参考文献]

[1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.

[2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.

[相关活性小分子]

1,4-丁二胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
159.0±8.0 °C at 760 mmHg

[ 熔点 ]:
27 °C

[ 分子式 ]:
C₄H₁₂N₂

[ 分子量 ]:
88.151

[ 闪点 ]:
51.7±0.0 °C

[ 精确质量 ]:
88.100044

[ PSA ]:
52.04000

[ LogP ]:
-0.72

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
2.6±0.3 mmHg at 25°C

[ 折射率 ]:
1.455

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品化工添加剂分开存放

[ 稳定性 ]:
Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents. Flammable.

[ 水溶解性 ]:
cell culture medium: 0.16 mg/mL

1,4-丁二胺MSDS

1,4-丁二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ6800000

CHEMICAL NAME :: 1,4-Butanediamine

CAS REGISTRY NUMBER :: 110-60-1

BEILSTEIN REFERENCE NO. :: 0605282

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C4-H12-N2

MOLECULAR WEIGHT :: 88.18

WISWESSER LINE NOTATION :: Z4Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 463 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Sense Organs and Special Senses (Eye) - ptosis Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1576 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - other changes in urine composition Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 314 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Liver

DOSE/DURATION :: 20 mmol/L

REFERENCE :: AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973- Volume(issue)/page/year: 33,149,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4958 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3 (estimated) No. of Female Employees: 3 (estimated)

1,4-丁二胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H311-H314-H330

[ 警示性声明 ]:
P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R20/21/22;R34

[ 安全声明 (欧洲) ]:
S16-S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2928 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
EJ6800000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2921290000

1,4-丁二胺合成路线

1,4-丁二胺上下游产品

1,4-丁二胺上游产品

1,4-丁二胺下游产品

1,4-丁二胺制备

1.由吡咯与盐酸羟胺反应得丁二肟，再经还原而得丁二胺。

1,4-丁二胺海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

1,4-丁二胺文献

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Antonie van Leeuwenhoek 108 , 619-26, (2015)

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