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n-丙酰基辅酶 A 锂盐

n-丙酰基辅酶 A 锂盐用途

丙基辅酶A锂是丙酸的辅酶A衍生物,是辅酶A与丙酸之间的硫酯键形成的重要代谢中间体。丙基辅酶A锂的分解和产生对生物体的新陈代谢很重要[1][2]。

n-丙酰基辅酶 A 锂盐名称

[ CAS 号 ]:
108321-21-7

[ 中文名 ]:
正丙酰基辅酶A锂盐

[ 英文名 ]:
Propionyl coenzyme A lithium

[英文别名 ]:

n-丙酰基辅酶 A 锂盐生物活性

[ 描述 ]:

丙基辅酶A锂是丙酸的辅酶A衍生物,是辅酶A与丙酸之间的硫酯键形成的重要代谢中间体。丙基辅酶A锂的分解和产生对生物体的新陈代谢很重要[1][2]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

丙基辅酶A锂因其积累及其代谢对结核分枝杆菌细胞壁合成和维持的影响而引起毒性作用[1]。在拟南芥中,丙基辅酶A锂可以通过过氧化物酶体酶修饰的β-氧化途径转化为β-羟基丙酸[2]。丙基辅酶A锂因其异常积累而导致丙酸血症的形成,通常发生在新生儿发育阶段[3]。

[参考文献]

[1]. Ernesto J Muñoz-Elías, et al. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol. 2006 Jun;60(5):1109-22.

[2]. Kerry A Lucas, et al. Peroxisomal metabolism of propionic acid and isobutyric acid in plants. J Biol Chem. 2007 Aug 24;282(34):24980-9.

[3]. Oleg A Shchelochkov, et al. Propionic Acidemia. 2012 May 17 [updated 2016 Oct 6]. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.

n-丙酰基辅酶 A 锂盐物理化学性质

[ 分子式 ]:
C₂₄H₄₀LiN₇O₁₇P₃S

[ 分子量 ]:
830.53800

[ 精确质量 ]:
830.15700

[ PSA ]:
425.34000

[ LogP ]:
1.33650

[ 储存条件 ]:
-20°C

n-丙酰基辅酶 A 锂盐MSDS

详细MSDS(安全技术说明书)

n-丙酰基辅酶 A 锂盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

n-丙酰基辅酶 A 锂盐文献

The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.

J. Bacteriol. 182 , 7007-7013, (2000)

The Saccharomyces cerevisiae ICL1 gene encodes isocitrate lyase, an essential enzyme for growth on ethanol and acetate. Previous studies have demonstrated that the highly homologous ICL2 gene (YPR006c...

Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases.

Environ. Microbiol. 13 , 1534-1548, (2011)

Gene duplication represents an evolutionary mechanism for expanding metabolic potential. Here we analysed the evolutionary relatedness of isocitrate and methylisocitrate lyases, which are key enzymes ...

The role of acyl-coenzyme A carboxylase complex in lipstatin biosynthesis of Streptomyces toxytricini.

Appl. Microbiol. Biotechnol. 87 , 1129-1139, (2010)

Streptomyces toxytricini produces lipstatin, a specific inhibitor of pancreatic lipase, which is derived from two fatty acid moieties with eight and 14 carbon atoms. The pccB gene locus in 10.6 kb fra...

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