醋酸齐考诺肽

醋酸齐考诺肽用途

Ziconotide 是一种止痛药,已用于治疗神经性和非神经性疼痛。Ziconotide 通过与位于伤害感受途径初级传入神经元末端的 N 型钙通道 (N-type calcium channels) 结合而起作用,从而减少突触传递并具有有效的抗伤害作用。

醋酸齐考诺肽名称

[ CAS 号 ]:
107452-89-1

[ 中文名 ]:
醋酸齐考诺肽

[ 英文名 ]:
ω-Conotoxin MVIIA

[英文别名 ]:

Ziconotide
ω-conotoxin MVIIA
SNX-111,Ziconotide
o-Conotoxin MVIIA
SNX-111 Ziconotide
snx111
Ziconotideacetate
Prialt
SNX-111
CKGKGAKCSRLMYDCCTGSCRSGKC-NH2

醋酸齐考诺肽生物活性

[ 描述 ]:

[ 靶点 ]

N-Type Ca2+ Channel

[参考文献]

[1]. Brinzeu A, et al. Ziconotide for spinal cord injury-related pain. Eur J Pain. 2019 Oct;23(9):1688-1700.

醋酸齐考诺肽物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 分子式 ]:
C₁₀₂H₁₇₂N₃₆O₃₂S₇

[ 分子量 ]:
2639.134

[ 精确质量 ]:
2637.098389

[ PSA ]:
1310.94000

[ LogP ]:
-17.05

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.710

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

醋酸齐考诺肽MSDS

详细MSDS(安全技术说明书)

醋酸齐考诺肽安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331

[ 警示性声明 ]:
P261-P304 + P340 + P312-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T+

[ 危险品运输编码 ]:
UN 3172

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

醋酸齐考诺肽文献

The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.

Cell. Mol. Neurobiol. 31(2) , 277-83, (2011)

In spinal cord synaptosomes, the spider toxin PhTx3-4 inhibited capsaicin-stimulated release of glutamate in both calcium-dependent and -independent manners. In contrast, the conus toxins, ω-conotoxin...

Rationale for Prospective Assays of Intrathecal Mixtures Including Morphine, Ropivacaine and Ziconotide: Prevention of Adverse Events and Feasibility in Clinical Practice.

Pain Physician 18 , 349-57, (2015)

Use of intrathecal admixtures is widespread, but compounding these is sometimes challenging and may result in errors and complications causing super-potency or sub potency adverse events in patients o...

Prolonged delirium with psychotic features from omega conotoxin toxicity.

Pain Med. 14(3) , 447-8, (2013)

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