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氧洛哌丁胺

氧洛哌丁胺用途

Loperamide oxide is a prodrug of the effective antidiarrheal loperamide.

氧洛哌丁胺名称

[ CAS 号 ]:
106900-12-3

[ 中文名 ]:
氧洛哌丁胺

[ 英文名 ]:
Loperamide

[英文别名 ]:

Loperamide N-oxide
Loperamide oxide
trans-N-Oxide of loperamide
Arestal

氧洛哌丁胺物理化学性质

[ 分子式 ]:
C₂₉H₃₃ClN₂O₃

[ 分子量 ]:
493.03700

[ 精确质量 ]:
492.21800

[ PSA ]:
69.97000

[ LogP ]:
5.05940

[ 水溶解性 ]:
Practically insoluble in water, freely soluble in alcohol and in methylene chloride.

氧洛哌丁胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM4960200

CHEMICAL NAME :: 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha -diphenyl-, 1-oxide, (E)-

CAS REGISTRY NUMBER :: 106900-12-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C29-H33-Cl-N2-O3

MOLECULAR WEIGHT :: 493.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 172 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

氧洛哌丁胺安全信息

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
TM4960200