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氯屈瞵酸

氯屈瞵酸用途

氯膦酸是一种口服活性双膦酸盐,用于研究骨质疏松症和与过度骨吸收相关的疾病。氯膦酸通过诱导破骨细胞凋亡抑制骨吸收。氯膦酸对维持或改善骨密度有效[1]。

氯屈瞵酸名称

[ CAS 号 ]:
10596-23-3

[ 中文名 ]:
氯膦酸二钠

[ 英文名 ]:
Clodronic Acid

[中文别名 ]:

[英文别名 ]:

Clodronic Acid
methanedichlorodiphosphonic acid
Acide clodronique
Acidum clodronicum
Bonefos
Acido clodronico
Clodronsaeure
Dichloromethylidene diphosphonate
(dichloromethylene)bisphosphonic acid
[dichloro(phosphono)methyl]phosphonic acid

氯屈瞵酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Frediani B, et al. Clodronic acid formulations available in Europe and their use in osteoporosis: a review. Clin Drug Investig. 2009;29(6):359-79.

氯屈瞵酸物理化学性质

[ 密度 ]:
2.3±0.1 g/cm3

[ 沸点 ]:
474.7±55.0 °C at 760 mmHg

[ 熔点 ]:
249-251°

[ 分子式 ]:
CH₄Cl₂O₆P₂

[ 分子量 ]:
244.892

[ 闪点 ]:
240.9±31.5 °C

[ 精确质量 ]:
243.886017

[ PSA ]:
134.68000

[ LogP ]:
-2.38

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
2-8°C，保存于惰性气体中

氯屈瞵酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7640500

CHEMICAL NAME :: Phosphonic acid, (dichloromethylene)bis-

CAS REGISTRY NUMBER :: 10596-23-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C-H4-Cl2-O6-P2

MOLECULAR WEIGHT :: 244.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/4D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,365,1987

氯屈瞵酸安全信息

[ 海关编码 ]:
2931900090

氯屈瞵酸制备

亚膦酸三异丙酯和二溴甲烷在搅拌下加热回流，蒸出未反应物，得油状的甲烷二膦酸四异丙酯。将其加入次氯酸钠溶液，反应，然后用氯仿萃取三次，合并氯仿液，减压蒸除大部分氯仿，冷却析出白色固体，即为二氯甲烷二膦酸四异丙酯。将其加入到1,1,2,2-四氯乙烷中，加热回流，减压蒸除1,1,2,2-四氯乙烷，得
到的油状物以异丙醚／氯仿重结晶，得氯膦酸。

氯屈瞵酸海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%