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NAAD sodium salt

NAAD sodium salt用途

NAAD钠盐(脱氨基nad钠盐)是一种功能性nad+前体,是谷氨酰胺依赖性nad+合成酶的底物。NAAD钠盐用于研究烟酸单核苷酸腺苷酸转移酶的结构[1][2]。

NAAD sodium salt名称

[ CAS 号 ]:
104809-30-5

[ 中文名 ]:
烟酸腺嘌呤二核苷酸钠盐

[ 英文名 ]:
NAAD sodium salt

[英文别名 ]:

Nicotinic acid NAD
Deamido NAD
Nicotinic acid adenine dinucleotide sodium salt
NAAD

NAAD sodium salt生物活性

[ 描述 ]:

NAAD钠盐(脱氨基nad钠盐)是一种功能性nad+前体,是谷氨酰胺依赖性nad+合成酶的底物。NAAD钠盐用于研究烟酸单核苷酸腺苷酸转移酶的结构[1][2]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

在外周血单个核细胞(PBMC)中,NAAD仅在色氨酸和NA2生物合成NAD+的过程中产生,从20%以下升高纳米到高达0.91纳米 μM[1]。烟酰胺腺嘌呤二核苷酸合成酶(NAD)催化烟酸腺嘌呤二核苷酸(NAAD)的酰胺化反应,产生辅酶因子烟酰胺腺嘌呤二核苷酸(NAD)[2]。

[体内研究]

在小鼠中,当通过口服灌胃提供烟酸(NA)时,肝脏NA达到峰值(340) pmol/mg)在15 最小值。肝脏NA出现后,在1.5%时预期峰值为220 NAAD 灌胃后h,肝脏NAD+从基线990升高至2小时的2200 h[1]。在小鼠肝脏中发现NAAD的时间为500小时将mg/kg放射性烟酰胺(Nam)腹腔注射(IP)至小鼠体腔。然而,在IP注射500的小鼠中,除肝脏外,在肾脏、卵巢、肺、心脏和大脑中也观察到NAAD NA(但不含Nam)的mg/kg[1]。

[参考文献]

[1]. Samuel A J Trammell, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948.

[2]. J Biol Chem. 2005 Apr 15;280(15):15131-40. Ralf Jauch, et al. Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.

NAAD sodium salt物理化学性质

[ 分子式 ]:
C₂₁H₂₅N₆NaO₁₅P₂

[ 分子量 ]:
686.39

[ 精确质量 ]:
686.07500

[ PSA ]:
337.75000

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

NAAD sodium saltMSDS

详细MSDS(安全技术说明书)

NAAD sodium salt安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

NAAD sodium salt文献

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.

Mol. Cell. 17 , 855-868, (2005)

Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases required for diverse biological processes, including transcriptional silencing, regulation of apoptosis, fat mobilization, and lifespa...

Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD.

Structure 10 , 69-79, (2002)

Nicotinamide/Nicotinate mononucleotide (NMN/NaMN) adenylyltransferase is an indispensable enzyme in both de novo biosynthesis and salvage of NAD+ and NADP+. In prokaryotes, it is absolutely required f...

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.

Biochemistry 42 , 9249-9256, (2003)

Life span regulation and inhibition of gene silencing in yeast have been linked to nicotinamide effects on Sir2 enzymes. The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene ...

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