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昂丹司琼盐酸盐二水合物

昂丹司琼盐酸盐二水合物用途

Ondansetron盐酸盐二水合物是5- HT3受体拮抗剂。

昂丹司琼盐酸盐二水合物名称

[ CAS 号 ]:
103639-04-9

[ 中文名 ]:
盐酸恩丹西酮

[ 英文名 ]:
Ondansetron hydrochloride

[中文别名 ]:

盐酸蒽丹西酮

[英文别名 ]:

2-Methylimdazole
ONDANSETRON HYDROCHLORIDE HYDRATE
MFCD00833882
1H-Imidazole, 2-methyl-
2-Methyl-1H-imidazole
methyl imidazole
2-Methylimidazole
Ondansetron Hydrochloride
ODANSETRON HYDROCHLORIDE
Ondansetron Hydrochloride Dihydrate

昂丹司琼盐酸盐二水合物生物活性

[ 描述 ]:

Ondansetron盐酸盐二水合物是5- HT3受体拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[参考文献]

[1]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65.

[2]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65.

[3]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.

[4]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16.

[5]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83.

[6]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31.

[相关活性小分子]

昂丹司琼盐酸盐二水合物物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
267.0±9.0 °C at 760 mmHg

[ 熔点 ]:
231-232ºC

[ 分子式 ]:
C₁₈H₂₄ClN₃O₃

[ 分子量 ]:
365.85

[ 闪点 ]:
144.9±5.1 °C

[ PSA ]:
58.28000

[ LogP ]:
-0.37

[ 外观性状 ]:
白色晶体粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
−20°C

昂丹司琼盐酸盐二水合物MSDS

详细MSDS(安全技术说明书)

昂丹司琼盐酸盐二水合物安全信息

[ 符号 ]:

GHS05, GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H318-H410

[ 警示性声明 ]:
P273-P280-P301 + P310-P305 + P351 + P338-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
FE6375500

昂丹司琼盐酸盐二水合物文献

Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.

Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014)

In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rod...

Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle.

Pharmazie 70(3) , 183-92, (2015)

DA-9701, a new prokinetic agent for the treatment of functional dyspepsia, is formulated with Pharbitis semen and Corydalis tuber. This study wasconducted to determine the pharmacological action of DA...

Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP).

BMC Pharmacol. Toxicol. 14 , 20, (2013)

Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has con...

更多文献

昂丹司琼盐酸盐二水合物

昂丹司琼盐酸盐二水合物用途

昂丹司琼盐酸盐二水合物名称

昂丹司琼盐酸盐二水合物生物活性

昂丹司琼盐酸盐二水合物物理化学性质

昂丹司琼盐酸盐二水合物MSDS

详细MSDS(安全技术说明书)

昂丹司琼盐酸盐二水合物安全信息

昂丹司琼盐酸盐二水合物文献

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