Erythromycin-d6
Modify Date: 2024-01-07 10:21:24
Erythromycin-d6 structure
|
Common Name | Erythromycin-d6 | ||
|---|---|---|---|---|
| CAS Number | 959119-25-6 | Molecular Weight | 739.964 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 818.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C37H61D6NO13 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 448.8±34.3 °C | |
Use of Erythromycin-d6Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1]. |
| Name | (3R,4S,5R,6R,7R,9R,11R,12S,13S,14R)-6-{[(2S,3R,4S,6R)-4-{Bis[(2H3)methyl]amino}-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name) |
|---|
| Description | Erythromycin-d6 is the deuterium labeled Erythromycin. Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
[2]. Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66(1):79-89. [4]. K Hamada, et al. Antitumor Effect of Erythromycin in Mice. Chemotherapy |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 818.4±65.0 °C at 760 mmHg |
| Molecular Formula | C37H61D6NO13 |
| Molecular Weight | 739.964 |
| Flash Point | 448.8±34.3 °C |
| Exact Mass | 739.498901 |
| LogP | 2.83 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.535 |