CPI-613

Modify Date: 2024-01-05 10:51:22

CPI-613 structure	Common Name	CPI-613
	CAS Number	95809-78-2	Molecular Weight	388.586
	Density	1.1±0.1 g/cm3	Boiling Point	553.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₈O₂S₂	Melting Point	63-65℃
	MSDS	Chinese	Flash Point	288.3±30.1 °C
	Symbol	GHS09	Signal Word	Warning

Use of CPI-613

CPI-613 is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.

Name	6,8-Bis(benzylsulfanyl)octanoic acid
Synonym	More Synonyms

Description	CPI-613 is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Zachar Z, Marecek J, Maturo C et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48. [2]. Lee KC, Shorr R, Rodriguez R et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab Lett. 2011 Aug;5(3):163-82. [3]. Safety and Effectiveness Study of CPI-613 to Treat Refractory or Relapsed Leukemia and Myelodysplastic Syndrome

Description

CPI-613 is a lipoic acid analog that inhibits pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts mitochondrial metabolism and shows strong antitumor activity.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

References

[1]. Zachar Z, Marecek J, Maturo C et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl). 2011 Nov;89(11):1137-48.

[2]. Lee KC, Shorr R, Rodriguez R et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab Lett. 2011 Aug;5(3):163-82.

[3]. Safety and Effectiveness Study of CPI-613 to Treat Refractory or Relapsed Leukemia and Myelodysplastic Syndrome

Density	1.1±0.1 g/cm3
Boiling Point	553.0±50.0 °C at 760 mmHg
Melting Point	63-65℃
Molecular Formula	C₂₂H₂₈O₂S₂
Molecular Weight	388.586
Flash Point	288.3±30.1 °C
Exact Mass	388.153076
PSA	87.90000
LogP	5.66
Appearance of Characters	white to beige
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.595
Storage condition	2-8°C
Water Solubility	DMSO: soluble15mg/mL (clear solution)

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
Hazard Codes	N
Risk Phrases	50/53
Safety Phrases	60-61
RIDADR	UN 3077 9 / PGIII

benzylthiol

CAS#:100-53-8

CPI-613

CAS#:95809-78-2

Literature: Journal of the American Chemical Society, , vol. 77, p. 416,418

sodium,6,8-bis(...

CAS#:36915-02-3

Benzyl bromide

CAS#:100-39-0

CPI-613

CAS#:95809-78-2

Literature: Gibson, Frank S.; Gupta, Deepak; Shorr, Robert; Rodriguez, Robert Organic Process Research and Development, 2011 , vol. 15, # 4 p. 855 - 857

Benzyl chloride

CAS#:100-44-7

CPI-613

CAS#:95809-78-2

Literature: Yakugaku Zasshi, , vol. 76, p. 943,945 Chem.Abstr., , p. 2562

Precursor 4
CAS#:100-53-8 benzylthiol CAS#:36915-02-3 sodium,6,8-bis(... CAS#:100-39-0 Benzyl bromide CAS#:100-44-7 Benzyl chloride
DownStream 0

6,8-bis-benzylsulfanyl-octanoic acid

6,8-Bis(benzylsulfanyl)octanoic acid

6,8-Bis-benzylmercapto-octansaeure

6,8-bis-benzylthio-octanoic acid

Octanoic acid, 6,8-bis[(phenylmethyl)thio]-

cc-429

QCR-193

(+/-)6,8-bis-thiobenzyl octanoic acid

CPI 613

UNII:E76113IR49

CPI-613

6,8-Bis(benzylthio)octanoic acid

DC Chemicals Limited
China
Product Name: CPI-613
Price: $250.0/100mg $450.0/250mg $900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CPI-613
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $66/10mM*1mLinDMSO

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CPI-613

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