(E)-methyl isoeugenol

Modify Date: 2024-01-03 23:19:17

(E)-methyl isoeugenol structure	Common Name	(E)-methyl isoeugenol
	CAS Number	93-16-3	Molecular Weight	178.23
	Density	1.0±0.1 g/cm3	Boiling Point	271.1±20.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₄O₂	Melting Point	98-100 °C(lit.)
	MSDS	Chinese USA	Flash Point	104.5±21.3 °C

Use of (E)-methyl isoeugenol

Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active[1].

Name	isomethyleugenol
Synonym	More Synonyms

Description	Methyl isoeugenol (MIE) is a natural food flavour that can be isolated from Pimenta pseudocaryophyllus leaf. Methyl isoeugenol shows anxiolytic and antidepressant like effects. Methyl isoeugenol is orally active[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Fajemiroye JO, et al. Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol. Food Funct. 2014 Aug;5(8):1819-28.

Density	1.0±0.1 g/cm3
Boiling Point	271.1±20.0 °C at 760 mmHg
Melting Point	98-100 °C(lit.)
Molecular Formula	C₁₁H₁₄O₂
Molecular Weight	178.23
Flash Point	104.5±21.3 °C
Exact Mass	178.099380
PSA	18.46000
LogP	3.05
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.534
Storage condition	2~8°C

(E)-methyl isoeugenol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ7000000

CHEMICAL NAME :: Benzene, 1,2-dimethoxy-4-propenyl-

CAS REGISTRY NUMBER :: 93-16-3

BEILSTEIN REFERENCE NO. :: 0880472

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C11-H14-O2

MOLECULAR WEIGHT :: 178.25

WISWESSER LINE NOTATION :: 2U1R CO1 DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,865,1975 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,865,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 199,226,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 181 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 199,226,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,865,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in leukocyte (WBC) count

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,475,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83230 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 207 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83230 No. of Facilities: 1391 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 15097 (estimated) No. of Female Employees: 10177 (estimated)

Hazard Codes	Xn
Risk Phrases	R36/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	CZ7000000
HS Code	2909309090

carbon monoxide

CAS#:201230-82-2

Methyleugenol

CAS#:93-15-2

~7%

1,2-dihydro-6,7...

CAS#:35491-96-4

Benzenepropanal...

CAS#:50838-61-4

Detail

Literature: Catalysis Communications, , vol. 11, # 8 p. 778 - 782

carbon monoxide

CAS#:201230-82-2

Methyleugenol

CAS#:93-15-2

2-(3,4-dimethox...

CAS#:50838-60-3

Benzenepropanal...

CAS#:50838-61-4

Detail

Literature: EP1719752 A1, ; Page/Page column 6-7 ;

Isoeugenol,mixt...

CAS#:97-54-1

methyl iodide

CAS#:74-88-4

(E)-methyl isoe...

CAS#:93-16-3

Literature: Kuo; Lin Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 9 p. 1507 - 1512

Isoeugenol,mixt...

CAS#:97-54-1

Dimethyl sulfate

CAS#:77-78-1

(E)-methyl isoe...

CAS#:93-16-3

Literature: Chem. Zentralbl., , vol. 80, # I p. 924 Gazzetta Chimica Italiana, , vol. 39 I, p. 208 Archiv der Pharmazie (Weinheim, Germany), , vol. 248, p. 143 Chem. Zentralbl., , vol. 80, # I p. 923

ethylmagnesium ...

CAS#:10467-10-4

veratraldehyde

CAS#:120-14-9

(E)-methyl isoe...

CAS#:93-16-3

Literature: Bulletin de la Societe Chimique de France, , vol. <4> 3, p. 316 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 141, p. 597

1-(3',4'-Dimeth...

CAS#:10548-83-1

(E)-methyl isoe...

CAS#:93-16-3

Literature: Bulletin de la Societe Chimique de France, , vol. <4> 3, p. 316 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 141, p. 597

carbon monoxide

CAS#:201230-82-2

Methyleugenol

CAS#:93-15-2

Benzenepropanal...

CAS#:50838-61-4

4-(3,4-methylen...

CAS#:52417-29-5

Detail

Literature: Advanced Synthesis and Catalysis, , vol. 347, # 11-13 p. 1488 - 1494

Methyleugenol

CAS#:93-15-2

(E)-methyl isoe...

CAS#:93-16-3

Literature: Chemische Berichte, , vol. 23, p. 862 Chemische Berichte, , vol. 23, p. 1165 Annales de Chimie (Cachan, France), , vol. <7> 15, p. 121

ETHYLMAGNESIUM ...

CAS#:925-90-6

veratraldehyde

CAS#:120-14-9

(E)-methyl isoe...

CAS#:93-16-3

Literature: Bulletin de la Societe Chimique de France, , vol. <4> 3, p. 316 Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 141, p. 597

Precursor 9
CAS#:201230-82-2 carbon monoxide CAS#:93-15-2 Methyleugenol CAS#:97-54-1 Isoeugenol,mixt... CAS#:74-88-4 methyl iodide
CAS#:77-78-1 Dimethyl sulfate CAS#:10467-10-4 ethylmagnesium ... CAS#:120-14-9 veratraldehyde CAS#:10548-83-1 1-(3',4'-Dimeth...
CAS#:925-90-6 ETHYLMAGNESIUM ...
DownStream 9
CAS#:5629-55-0 2,3,6,7-Tetrame... CAS#:120-14-9 veratraldehyde CAS#:93-07-2 Veratric acid CAS#:20133-19-1 UNII:N6222F124L
CAS#:37803-49-9 1-(3,4-dimethox... CAS#:4483-47-0 Diisohomoeugenol CAS#:776-99-8 3,4-Dimethoxyph... CAS#:4732-70-1 2-(3,4-dimethox...
CAS#:5888-52-8 1,2-DIMETHOXY-4...

HS Code	2909309090
Summary	2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Neural coding of binary mixtures in a structurally related odorant pair.

Sci. Rep. 3 , 1220, (2013)

The encoding of odorant mixtures by olfactory sensory neurons depends on molecular interactions at peripheral receptors. However, the pharmacological basis of these interactions is not well defined. B...

Chemical composition of the essential oil of Feronia elephantum Correa.

Nat. Prod. Res. 24(19) , 1807-10, (2010)

The essential oil composition of Feronia elephantum Correa (family: Rutaceae) was examined by capillary gas chromatography (GC) and gas chromatography-mass spectroscopy (GC-MS). The analysis revealed ...

A call for full ingredient labelling and uniform nomenclature on medicaments.

Br. J. Dermatol. 161(2) , 489-90, (2009)

4-Propenylveratrole

1,3,4-Isoeugenol methyl ether

trans-Methylisoeugenol

isomethyleugenol

4-trans-Propenylveratrole

benzene, 1,2-dimethoxy-4-(1-propen-1-yl)-

1,2-Dimethoxy-4-((E)-propenyl)-benzene

1-Propene, 1-(3,4-dimethoxyphenyl)-

Isoeugenyl methyl ether

trans-Methyl isoeugenol

1,2-dimethoxy-4-[(1E)-prop-1-en-1-yl]benzene

1,2-Dimethoxy-4-[(1E)-1-propen-1-yl]benzene

1-(3, 4-Dimethoxyphenyl)-1-propene

1,2-dimethoxy-4-prop-1-en-1-ylbenzene

Methylisoeugenol

MFCD00009282

EINECS 202-224-6

Benzene, 1,2-dimethoxy-4-[(1E)-1-propen-1-yl]-

trans-isomethyleugenol

Methyl isoeugenol

Isoeugenol methyl ether

trans-4-Propenylveratrole

1,2-Dimethoxy-4-propenylbenzene

Benzene, 1,2-dimethoxy-4-propenyl-, (E)-

1,2-Dimethoxy-4-(prop-1-en-1-yl)benzene

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (E)-methyl isoeugenol
Price: ￥278.0/100ml ￥98.0/25ml
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Methyl isoeugenol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,3,4-Isoeugenol methyl ether
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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(E)-methyl isoeugenol

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