methacycline

Modify Date: 2024-01-08 20:22:12

methacycline Structure
methacycline structure
Common Name methacycline
CAS Number 914-00-1 Molecular Weight 442.41900
Density 1.66g/cm3 Boiling Point 695.1ºC at 760mmHg
Molecular Formula C22H22N2O8 Melting Point >150°C (dec.) (lit.)
MSDS N/A Flash Point 374.2ºC

 Names

Name methacycline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.66g/cm3
Boiling Point 695.1ºC at 760mmHg
Melting Point >150°C (dec.) (lit.)
Molecular Formula C22H22N2O8
Molecular Weight 442.41900
Flash Point 374.2ºC
Exact Mass 442.13800
PSA 181.62000
LogP 0.26240
Index of Refraction 1.753
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QI9275000
CHEMICAL NAME :
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
CAS REGISTRY NUMBER :
914-00-1
LAST UPDATED :
199506
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C22-H22-N2-O8
MOLECULAR WEIGHT :
442.46
WISWESSER LINE NOTATION :
L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
3750 ug/L
REFERENCE :
BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year: 16,127,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1538 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated)

 Synonyms

Germicilclin
Adriamicina
gs-2876
6-methylene-oxytetracyclin
METHACYCLINE
Globociclina
6-methyleneoxytetracycline
rondomycin
metacycline
bialatan
methacyclineamphoteric
Cyclobiotic
12aalpha))-ph
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