Bedaquiline

Modify Date: 2024-01-02 20:31:53

Bedaquiline structure	Common Name	Bedaquiline
	CAS Number	843663-66-1	Molecular Weight	555.50
	Density	1.3±0.1 g/cm3	Boiling Point	702.7±60.0 °C at 760 mmHg
	Molecular Formula	C₃₂H₃₁BrN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	378.8±32.9 °C

Use of Bedaquiline

Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase.

Name	tmc-207
Synonym	More Synonyms

Description	Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
Target	mycobacterial ATP synthase[1]
In Vitro	Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3].
References	[1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20. [2]. Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5). [3]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.

Density	1.3±0.1 g/cm3
Boiling Point	702.7±60.0 °C at 760 mmHg
Molecular Formula	C₃₂H₃₁BrN₂O₂
Molecular Weight	555.50
Flash Point	378.8±32.9 °C
PSA	36.36000
LogP	7.59
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.666
Storage condition	-20℃

Precursor 5
CAS#:1229443-16-6 (3S,4R)-4-(6-br... CAS#:124-40-3 Dimethylamine CAS#:1298044-25-3 (2R)-2-(6-bromo... CAS#:1298044-31-1 (4R)-4-(6-bromo...
CAS#:1298044-13-9 ethyl (E)-3-(6-...
DownStream 0

methyl 6-azanyl-2-benzamido-hexanoate hydrochloride

BZ-LYS-OME HCL

Sirturo

methyl (2S)-6-amino-2-benzamidohexanoate

Bedaquiline

6-amino-2-benzamidohexanoic acid methyl ester hydrochloride

(1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol

3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-

(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol

TMC207

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Bedaquiline
Price: ￥716.0/2mg ￥1736.0/10mg ￥6016.0/50mg ￥1126.0/5mg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Bedaquiline (TMC207)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Bedaquiline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Bedaquiline suppliers

Price: $73/10mM*1mLinDMSO

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