Sulconazole (nitrate)

Modify Date: 2024-01-11 09:11:59

Sulconazole (nitrate) structure	Common Name	Sulconazole (nitrate)
	CAS Number	82382-23-8	Molecular Weight	460.76
	Density	N/A	Boiling Point	558.2ºC at 760 mmHg
	Molecular Formula	C₁₈H₁₅Cl₃N₂S_.HNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	291.4ºC

Use of Sulconazole (nitrate)

Sulconazole nitrate is an antifungal medication of the imidazole class.

Name	1-[2-(4-Chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole nitrate
Synonym	More Synonyms

Description	Sulconazole nitrate is an antifungal medication of the imidazole class.
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection
Target	Antifungal[1][2]
In Vivo	After cutaneous application of radioactive solutions of Sulconazole nitrate in the hairless rat, the total absorption of the substance by the skin, estimated from the sum of the cumulative urinary and fecal excretions over 96 h, is 2.4% of the dose administered. The elimination reaches a maximum between 6 and 24 h and is virtually complete after 96 h. The excretion is almost equally distributed between the urine and the feces, which corresponds to an intense elimination via the biliary tract. The quantities present in the stratum corneum, epidermis and dermis at the end of the period of contact constituted another estimation of the total absorption of the substance which confirmed the previous estimation (3.6% of the dose). The measurement of the concentrations of Sulconazoleand its metabolites in the various layers of the skin reveals a high affinity of the substance for the stratum corneum, where it remains present in large quantities for more than 48 h. This affinity is due to the very intense lipophilia of the molecule. The concentrations in the other tissues are inversely proportional to the distance from the surface of the skin and are virtually nil in the circulating blood[3].
References	[1]. Zaro BA, et al. Species variation in percutaneous absorption of sulconazole nitrate, a new anti-fungal agent. Proc West Pharmacol Soc. 1982;25:357-9. [2]. Bielejewska A, et al. Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column. J Chromatogr A. 2005 Aug 12;1083(1-2):133-40. [3]. Hercelin B, et al. Pharmacokinetics of cutaneous Sulconazole nitrate in the hairless rat: absorption, excretion, tissue concentrations. Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):149-54.

Boiling Point	558.2ºC at 760 mmHg
Molecular Formula	C₁₈H₁₅Cl₃N₂S_.HNO₃
Molecular Weight	460.76
Flash Point	291.4ºC
PSA	109.17000
LogP	6.69350

HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Sulconazole (nitrate)

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sulconazole nitrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $79/10mM*1mLinDMSO

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