1,8-Dihydroxy-4,5-dinitroanthraquinone

Modify Date: 2024-01-03 10:07:15

1,8-Dihydroxy-4,5-dinitroanthraquinone structure	Common Name	1,8-Dihydroxy-4,5-dinitroanthraquinone
	CAS Number	81-55-0	Molecular Weight	330.206
	Density	1.8±0.1 g/cm3	Boiling Point	669.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₆N₂O₈	Melting Point	225 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	280.8±20.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of 1,8-Dihydroxy-4,5-dinitroanthraquinone

1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].

Name	1,8-Dihydroxy-4,5-dinitroanthraquinone
Synonym	More Synonyms

Description	1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].
Related Catalog	Research Areas >> Infection
In Vitro	1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM；90 分钟) 抑制 NS2B/3 裂解，并在 100 μM 时显着且显着地作用于 BHK-21 细胞[1]。
References	[1]. Constant DA, et al. Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10136-10141.

Density	1.8±0.1 g/cm3
Boiling Point	669.4±55.0 °C at 760 mmHg
Melting Point	225 °C (dec.)(lit.)
Molecular Formula	C₁₄H₆N₂O₈
Molecular Weight	330.206
Flash Point	280.8±20.0 °C
Exact Mass	330.012421
PSA	166.24000
LogP	4.94
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.782
Stability	Stable. Incompatible with strong oxidizing agents.

1,8-Dihydroxy-4,5-dinitroanthraquinone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6700000

CHEMICAL NAME :: Anthraquinone, 1,8-dihydroxy-4,5-dinitro-

CAS REGISTRY NUMBER :: 81-55-0

BEILSTEIN REFERENCE NO. :: 2182054

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H6-N2-O8

MOLECULAR WEIGHT :: 330.22

WISWESSER LINE NOTATION :: L C666 BVIVJ DQ GNW KNW NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CB6700000
HS Code	2914700090

Dantron

CAS#:117-10-2

~73%

1,8-Dihydroxy-4...

CAS#:81-55-0

Literature: Chang; Cheng Synthetic Communications, 1995 , vol. 25, # 13 p. 1893 - 1900

Dantron

CAS#:117-10-2

~76%

1,8-Dihydroxy-4...

CAS#:81-55-0

1,8-dihydroxy-2...

CAS#:39003-36-6

Literature: Chang Synthetic Communications, 1994 , vol. 24, # 7 p. 931 - 937

Precursor 1
CAS#:117-10-2 Dantron
DownStream 3
CAS#:81-60-7 1,4,5,8-Tetrahy... CAS#:128-94-9 9,10-Anthracene... CAS#:17418-72-3 4,5-diamino-9,1...

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Catalysed hydrogenation of hydroxynitroanthraquinones in strong acid. Morley JO and Hutcheson R.

J. Chem. Technol. Biotechnol. 30(1) , 409-414, (1980)

Measurement and Correlation of Derivatized Anthraquinone Solubility in Supercritical Carbon Dioxide. Alwi RS and Tamura K.

J. Chem. Eng. Data 60(10) , 3046-3052, (2015)

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4,5-dinitro-1,8-dihydroxyanthraquinone

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1,8-Dihydroxy-4,5-dinitroanthraquinone
Price: ￥388.0/5g ￥108.0/1g
Purity: 97.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: ARDP0006
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,8-Dihydroxy-4,5-dinitroanthraquinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥200/100 mg

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1,8-Dihydroxy-4,5-dinitroanthraquinone

Use of 1,8-Dihydroxy-4,5-dinitroanthraquinone

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