Musk ketone

Modify Date: 2024-01-02 17:58:03

Musk ketone Structure
Musk ketone structure
 Common Name Musk ketone
CAS Number 81-14-1 Molecular Weight 294.30
Density 1.2±0.1 g/cm3 Boiling Point 369.0±42.0 °C at 760 mmHg
Molecular Formula C14H18N2O5 Melting Point 135-139 °C(lit.)
MSDS Chinese USA Flash Point 153.2±20.7 °C
Symbol GHS08 GHS09
GHS08, GHS09		 Signal Word Warning

 Use of Musk ketone


Musk ketone (MK) is a widely used artificial fragrance. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].

 Names

Name musk ketone
Synonym More Synonyms

 Musk ketone Biological Activity

Description Musk ketone (MK) is a widely used artificial fragrance. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].
Related Catalog
References

[1]. Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26(5):656-62.

[2]. Mersch-Sundermann V, et al. Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495(1-2):89-96.

[3]. Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 369.0±42.0 °C at 760 mmHg
Melting Point 135-139 °C(lit.)
Molecular Formula C14H18N2O5
Molecular Weight 294.30
Flash Point 153.2±20.7 °C
Exact Mass 294.121582
PSA 108.71000
LogP 3.86
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.548
Stability Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
Water Solubility Insoluble (

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5775841
CHEMICAL NAME :
Ethanone, 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophen yl)-
CAS REGISTRY NUMBER :
81-14-1
BEILSTEIN REFERENCE NO. :
2062638
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H18-N2-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,877,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,877,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 26,656,1981

 Safety Information

Symbol GHS08 GHS09
GHS08, GHS09
Signal Word Warning
Hazard Statements H351-H410
Precautionary Statements P273-P281-P501
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F: Flammable;Xn: Harmful;
Risk Phrases R11
Safety Phrases S16-S36/37
RIDADR UN1648 3/PG 2
WGK Germany 2
RTECS KM5775841
Hazard Class 3.0

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles37

More Articles
Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE).

Anal. Chim. Acta 851 , 1-13, (2014)

This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrin...

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Regul Toxicol Pharmacol 72 , 578-85, (2015)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...

On-line coupling of solid-phase extraction to gas chromatography-mass spectrometry to determine musk fragrances in wastewater.

J. Chromatogr. A. 1364 , 1-11, (2014)

An on-line coupling solid-phase extraction (SPE) has been developed for the first time to preconcentrate trace amounts of 17 musk fragrances extensively used in personal care products (6 polycyclic mu...

 Synonyms

KETONE MOSCHUS
Acetophenone, 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitro- (8CI)
4-acetyl-1-tert-butyl-3,5-dimethyl-2-nitro-6-aminobenzene
2-acetyl-5-tert-butyl-4,6-dinitroxylene
3-METHYLCYCLOPENTADECANONE (D,L-MUSCONE)
EINECS 201-328-9
1-tert-butyl-3,5-dimethyl-2,6-dinitro-4-acetylbenzene
4'-tert-butyl-2',6'-dimethyl-3',5'-dinitroacetophenone
4-tert-butyl-3,5-dinitro-2,6-dimethyl-acetophenone
MOSCHUS
3,5-dinitro-2,6-dimethyl-4-t-butylacetophenone
1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanone
Ketone musk
1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanon
Dinitro-tert-butylxylyl methyl ketone
MOSCHUS KETON
Ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-
Musk ketone
MFCD00024271
Acetyl-dinitro-butyl-xylene
1-[2,6-Dimethyl-4-(2-methyl-2-propanyl)-3,5-dinitrophenyl]ethanone
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Chemsrc provides Musk ketone(CAS#:81-14-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Musk ketone are included as well.>> amp version: Musk ketone

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