Vebufloxacin

Modify Date: 2024-01-08 18:07:56

Vebufloxacin Structure
Vebufloxacin structure
Common Name Vebufloxacin
CAS Number 79644-90-9 Molecular Weight 359.39500
Density 1.41g/cm3 Boiling Point 579.1ºC at 760 mmHg
Molecular Formula C19H22FN3O3 Melting Point N/A
MSDS N/A Flash Point 304ºC

 Use of Vebufloxacin


DM8966 exhibits potent antibacterial activity against gram-positive and -negative bacteria.

 Names

Name Vebufloxacin
Synonym More Synonyms

 Vebufloxacin Biological Activity

Description DM8966 exhibits potent antibacterial activity against gram-positive and -negative bacteria.
Related Catalog
Target

Bacteria[1]

In Vitro A series of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids is synthesized and tested for antibacterial activities. Among them, DM8966 (OPC-7241) exhibits potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa, and OPC-7251 shows potent activity characteristically against Propionibacterium acnes[1].
References

[1]. Ishikawa H, et al. Studies on antibacterial agents. I. Synthesis of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids. Chem Pharm Bull (Tokyo). 1989 Aug;37(8):2103-8.

 Chemical & Physical Properties

Density 1.41g/cm3
Boiling Point 579.1ºC at 760 mmHg
Molecular Formula C19H22FN3O3
Molecular Weight 359.39500
Flash Point 304ºC
Exact Mass 359.16500
PSA 65.78000
LogP 2.10070
Index of Refraction 1.661

 Synthetic Route

 Synonyms

Benofloxacin
8-(4-methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
UNII-SXI3MP1G46
1h,5h-benzo[ij]quinolizine-2-carboxylic acid,9-fluoro-6,7-dihydro-5-methyl-8-(4-methyl-1-piperazinyl)-1-oxo
9-Fluoro-5-methyl-8-(4-methyl-1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo<ij>quinolizine-2-carboxylic acid
DM8966
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