Morachalcone A

Modify Date: 2024-01-02 16:02:23

Morachalcone A Structure
Morachalcone A structure
Common Name Morachalcone A
CAS Number 76472-88-3 Molecular Weight 340.37
Density 1.3±0.1 g/cm3 Boiling Point 605.0±55.0 °C at 760 mmHg
Molecular Formula C20H20O5 Melting Point N/A
MSDS N/A Flash Point 333.7±28.0 °C

 Use of Morachalcone A


Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].

 Names

Name (2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dih ydroxyphenyl)-2-propen-1-one
Synonym More Synonyms

 Morachalcone A Biological Activity

Description Morachalcone A is a naturally-occurring aromatase inhibitor (IC50=4.6 mM). Morachalcone A is also a plants metabolite with potential anti-inflammatory and anticancer activity. Morachalcone A inhibits Lipopolysaccharide (HY-D1056)-induced nitric oxide production[1][2][3].
Related Catalog
References

[1]. Brandt D R, et al. The synthetic preparation of naturally-occurring aromatase inhibitors, morachalcone A, isogemichalcone B, and isogemichalcone C[J]. Tetrahedron, 2013, 69(47): 9994-10002.

[2]. Kang Y J, et al. Inhibitory effects of morachalcone A on lipopolysaccharide-induced nitric oxide production in raw 264.7 cells[J]. 2009.

[3]. Ferlinahayati, et al. Phenolic constituents from the wood of Morus australis with cytotoxic activity. Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):35-9.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 605.0±55.0 °C at 760 mmHg
Molecular Formula C20H20O5
Molecular Weight 340.37
Flash Point 333.7±28.0 °C
Exact Mass 340.131073
PSA 97.99000
LogP 5.24
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.680

 Safety Information

Hazard Codes Xi

 Synonyms

2-Propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-, (2E)-
morachalchone A
BENZALACETOPHENONE
2,4,2',4'-tetrahydroxy-3'-prenylchalcone
MorachalconeA
Morachalcone A
1,3-diphenylprop-1-en-3-one
BENZYLIDENEACETOPHENONE
3-PHENYLACRYLOPHENONE
2-BENZALACETOPHENONE
1,3-di-phenyl-prop-2-en-1-one
(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one
trans-1,3-diphenyl-2-propen-1-one
PHENYL STYRYL KETONE
1,3-diphenyl-2-propen-1-one
TRANS-CHALCONE