Rubiadin 1-methyl ether

Modify Date: 2024-01-11 20:35:32

Rubiadin 1-methyl ether Structure
Rubiadin 1-methyl ether structure
Common Name Rubiadin 1-methyl ether
CAS Number 7460-43-7 Molecular Weight 268.264
Density 1.4±0.1 g/cm3 Boiling Point 502.2±50.0 °C at 760 mmHg
Molecular Formula C16H12O4 Melting Point N/A
MSDS N/A Flash Point 193.0±23.6 °C

 Use of Rubiadin 1-methyl ether


Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

 Names

Name rubiadin 1-methyl ether
Synonym More Synonyms

 Rubiadin 1-methyl ether Biological Activity

Description Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].
Target

p65

References

[1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 502.2±50.0 °C at 760 mmHg
Molecular Formula C16H12O4
Molecular Weight 268.264
Flash Point 193.0±23.6 °C
Exact Mass 268.073547
PSA 63.60000
LogP 3.92
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.649

 Safety Information

Hazard Codes Xi
HS Code 2914690090

 Synthetic Route

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Rubiadin 1-methyl ether Structure

Rubiadin 1-meth...

CAS#:7460-43-7

Literature: Molecules, , vol. 18, # 8 p. 10042 - 10055

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Rubiadin 1-methyl ether Structure

Rubiadin 1-meth...

CAS#:7460-43-7

Literature: Journal of the Chemical Society, , p. 1699,1707

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Rubiadin 1-methyl ether Structure

Rubiadin 1-meth...

CAS#:7460-43-7

Literature: Journal of the Chemical Society [Section] C: Organic, , p. 854 - 857

 Customs

HS Code 2914690090
Summary 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

9,10-Anthracenedione, 3-hydroxy-1-methoxy-2-methyl-
9,10-Anthracenedione,3-hydroxy-1-methoxy-2-methyl
3-Hydroxy-1-methoxy-2-methylanthraquinone
1,3-dimethoxy-2-methylanthraquinone
3-Hydroxy-1-methoxy-2-methyl-anthraquinone
3-Hydroxy-1-methoxy-2-methyl-9,10-anthraquinone
rubiadin-1-methyl ether
3-Hydroxy-1-methoxy-2-methyl-anthrachinon
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