Ethoxylated hydrogenated castor oil

Modify Date: 2024-01-02 18:20:12

Ethoxylated hydrogenated castor oil Structure
Ethoxylated hydrogenated castor oil structure
Common Name Ethoxylated hydrogenated castor oil
CAS Number 61788-85-0 Molecular Weight 375.864
Density 1.2±0.1 g/cm3 Boiling Point 529.0±50.0 °C at 760 mmHg
Molecular Formula C21H23ClFNO2 Melting Point N/A
MSDS USA Flash Point 273.8±30.1 °C

 Use of Ethoxylated hydrogenated castor oil


Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo[1].

 Names

Name Ethoxylated hydrogenated castor oil
Synonym More Synonyms

 Ethoxylated hydrogenated castor oil Biological Activity

Description Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo[1].
Related Catalog
In Vivo 20% PEG-40 hydrogenated castor oil (10 μl) is applied to the left ear of the mouse, and the right ear served as a control. The mice are observed for development of erthyma for 6 days, no signs of irritation are observed in the mice[1]. PEG-40 hydrogenated castor oil (injection via the tail vein; 300, 900, and 2700 mg/kg; 4 weeks) is administared for short-term toxicity. At doses of 300 and 900 mg/kg PEG-40 Hydrogenated Castor Oi exhibits no systemic toxicity. However, at a dose of 2700 mg/kg, slight ataxia is observed and body weight is reduced significantly in the males and slightly in the females[1]. A toxicity study of blank nanoemulsion using PEG-40 hydrogenated castor oil as a surfactant is applied in order to load various active compounds for oral administration[2]. Nearly 20% of PEG-40 hydrogenated castor oil was used to emulsify the glyceryl monooleate (GMO) as an oil to the aqueous phase. In Webster mice, 5000 mg/kg blank nanoemulsion is given orally to mice once a day for 14 days, this nanoemulsion does not produce hazardous effects, and it has no effect on food intake[2].
References

[1]. PEG-40 HYDROGENATED CASTOR OIL

[2]. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018.

[3]. PEGylated Oils as Used in Cosmetics

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 529.0±50.0 °C at 760 mmHg
Molecular Formula C21H23ClFNO2
Molecular Weight 375.864
Flash Point 273.8±30.1 °C
Exact Mass 375.140137
LogP 3.01
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.581

 Safety Information

RIDADR NONH for all modes of transport

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 Synonyms

Brotopon
Einalon S
Eukystol
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Peluces
Haldol
Halosten
Linton
Aloperidin
4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone
Sigaperidol
Butyrophenone, 4-[4- (p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro-
haloperidol
Haloperidol [USAN:BAN:INN:JAN]
1-Butanone, 4-[4- (4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-
1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Serenace
4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorphenyl)butan-1-on
Bioperidolo
Dozic
Keselan