Tanshinone IIA

Modify Date: 2024-01-01 23:19:01

Tanshinone IIA Structure
Tanshinone IIA structure
 Common Name Tanshinone IIA
CAS Number 568-72-9 Molecular Weight 294.344
Density 1.2±0.1 g/cm3 Boiling Point 480.7±44.0 °C at 760 mmHg
Molecular Formula C19H18O3 Melting Point 205-207ºC
MSDS Chinese USA Flash Point 236.4±21.1 °C

 Use of Tanshinone IIA


Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

 Names

Name Tanshinone IIA
Synonym More Synonyms

 Tanshinone IIA Biological Activity

Description Tanshinone IIA (Tan IIA) is one of the main fat-soluble compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
Related Catalog
Target

VEGF/VEGFR2[1]
In Vitro The anti-tumor effect of Tanshinone IIA includes inhibiting tumor cell proliferation, disturbing tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer. Tanshinone IIA has anti-proliferative effects on A549 cells: the IC50 of Tanshinone IIA after 24, 48 and 72 h are 145.3, 30.95 and 11.49 μM, respectively. The CCK-8 assay is used to evaluate the proliferative activity of A549 cells treated with Tanshinone IIA (2.5-80 μM) for 24, 48 and 72 h, respectively. The CCK-8 results show that Tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Obvious apoptosis and cell growth inhibition of A549 cells are observed after drug treatment for 48 h (concentrations used are approximately IC50 values: Tanshinone IIA 31 μM on A549). Western blotting finds that 48 h exposures to Tanshinone IIA (31 μM) in A549 cells, downregulates expression of VEGF and VEGFR2 protein in both drug treatment groups vs. vehicle[1]. Tanshinone IIA, one of the most abundant constituents of the root of Salvia miltiorrhiza, protects rat myocardium-derived H9C2 cells against apoptosis. Treatment of H9C2 cells with Tanshinone IIA inhibits angiotensin II-induced apoptosis by downregulating the expression of PTEN (phosphatase and tensin homolog), a tumor suppressor that plays a critical role in apoptosis. Tanshinone IIA inhibits angiotensin II (AngII)-induced apoptosis by downregulating the expression of phosphatase and tensin homolog (PTEN)[2]. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells[3].
Cell Assay A549 cells are counted in logarithmic phase and 6000 cells (90 μL volume) are placed in 96-well plates. 10 μL varying concentrations of Tanshinone IIA (final concentrations 80, 60, 40, 30, 20, 15, 10, 5 and 2.5 μM) and ADM (final concentrations 8, 4, 2, 1, 0.5 and 0.25 μM) are added into drug groups, while negative control group (vehicle group) is only added 10 μL DMSO or normal saline without Tanshinone IIA or ADM. Cells are incubated for an additional 2 h with CCK-8 reagent (100 μL/mL medium) and the absorbance is read at 450 nm using a microplate reader. Cell proliferation inhibition rates are calculated according to the following formula: the proliferation inhibition ratio (%)=1-[(A1-A4)/(A2-A3)]×100, where, A1 is the OD value of drug experimental group, A2 is the OD value of blank control group, A3 is the OD value of the RPMI1640 medium without cells, and A4 is the OD value of drugs with the same concentration as A1 but without cells. The IC50 value, which represents the concentration of the drug that demonstrates 50% of cell growth inhibition, is calculated by nonlinear regression analysis using GraphPad Prism software[1].
References

[1]. Xie J, et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63.

[2]. Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32.

[3]. Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 480.7±44.0 °C at 760 mmHg
Melting Point 205-207ºC
Molecular Formula C19H18O3
Molecular Weight 294.344
Flash Point 236.4±21.1 °C
Exact Mass 294.125580
PSA 47.28000
LogP 5.47
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.588
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Synthetic Route

 Articles57

More Articles
The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts.

Br. J. Pharmacol. 171(12) , 2993-3009, (2014)

Infection with Gram-negative bacteria has been recognized as an initiator of rheumatoid arthritis, which is characterized by chronic inflammation and infiltration of immune cells. Carbon monoxide (CO)...
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").

J. Nat. Prod. 76(1) , 36-44, (2013)

The roots of Salvia miltiorrhiza ("Danshen") are used in traditional Chinese medicine for the treatment of numerous ailments including cardiovascular disease, hypertension, and ischemic stroke. Extrac...
Surfactant-coated graphitized multiwalled carbon nanotubes as the pseudostationary phase in electrokinetic chromatography for the analysis of phytochemical compounds in biological fluids.

Electrophoresis 36(7-8) , 1055-63, (2015)

This report describes the use of surfactant-coated graphitized multiwalled carbon nanotubes (SC-GMWNTs) as a novel pseudostationary phase in CE with diode array detection for the determination of phen...

 Synonyms

Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-
Tanshinone IIA
tanshinone II-A
Dan Shen Ketone
Tanshionesiia
Tanshine II
TANSHION P.E
1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
SweetOrange
MFCD00238692
QS-D-77-4-2
TANSHINONE A
tanshiones
Tanshinone II
TANSHINONES IIA
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Tanshinone IIA
  • Price: ￥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

Get all suppliers and price by the below link:

Tanshinone IIA suppliers

Price: ￥452.4/10mg

Reference only. check more Tanshinone IIA price

Related Compounds: More...
tanshinone IIA
100210-65-9
Isotanshinone IIA
20958-15-0
Hydroxytanshinone IIA
18887-18-8
Tanshinone IIA anhydride
61077-78-9
Tanshinone IIA sodium sulfonate
69659-80-9
tanshinone VI
121064-74-2
Tanshinone IIB
17397-93-2
Tanshinone I
568-73-0
Euglobal Iia
77844-92-9
Chemsrc provides Tanshinone IIA(CAS#:568-72-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tanshinone IIA are included as well.>> amp version: Tanshinone IIA

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved