3-(2,4-Dihydroxyphenyl)propionic acid

Modify Date: 2024-01-02 15:45:57

3-(2,4-Dihydroxyphenyl)propionic acid Structure
3-(2,4-Dihydroxyphenyl)propionic acid structure
Common Name 3-(2,4-Dihydroxyphenyl)propionic acid
CAS Number 5631-68-5 Molecular Weight 182.173
Density 1.4±0.1 g/cm3 Boiling Point 418.0±14.0 °C at 760 mmHg
Molecular Formula C9H10O4 Melting Point 158-162ºC
MSDS Chinese USA Flash Point 220.8±16.6 °C

 Use of 3-(2,4-Dihydroxyphenyl)propionic acid


3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively[1].

 Names

Name 3-(2,4-Dihydroxyphenyl)propanoic acid
Synonym More Synonyms

 3-(2,4-Dihydroxyphenyl)propionic acid Biological Activity

Description 3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively[1].
Related Catalog
Target

Ki: 3.02 μM (L-Tyrosine); 11.5 μM (DL-DOPA)[1]

References

[1]. Shimizu K, et al. Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties. Lipids. 2001 Dec;36(12):1321-6.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 418.0±14.0 °C at 760 mmHg
Melting Point 158-162ºC
Molecular Formula C9H10O4
Molecular Weight 182.173
Flash Point 220.8±16.6 °C
Exact Mass 182.057907
PSA 77.76000
LogP 0.38
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.620

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918290000

 Synthetic Route

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Articles4

More Articles
The use of enzyme-coupled magnetic nanoparticles for studying the spectra of unusual substrates of mushroom tyrosinase by direct surface-assisted laser desorption/ionisation and high-resolution electrospray ionisation quadrupole-quadrupole-time-of-flight mass spectrometry.

Rapid Commun. Mass Spectrom. 28(18) , 1957-63, (2014)

Tyrosinase-coupled magnetic particles (EMPs) were used to demonstrate that resorcinol-containing tyrosinase inhibitors are oxidised by tyrosinase only in the presence of the enzyme's classic substrate...

The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage.

Biochem. J. 330 ( Pt 3) , 1059-67, (1998)

A major product of hydroxy-radical addition to tyrosine is 3, 4-dihydroxyphenylalanine (DOPA) which has reducing properties. Protein-bound DOPA (PB-DOPA) has been shown to be a major component of the ...

Phenoloxidase and QX disease resistance in Sydney rock oysters (Saccostrea glomerata).

Dev. Comp. Immunol. 28(6) , 565-9, (2004)

QX is a fatal disease in Sydney rock oysters (Saccostrea glomerata) that results from infection by the protistan parasite, Marteilia sydneyi. Since 1997, the New South Wales Fisheries Service has bred...

 Synonyms

3-(2,4-Dihydroxyphenyl)propanoic acid
Benzenepropanoic acid, 2,4-dihydroxy-
MFCD00143017