2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE

Modify Date: 2024-01-03 17:21:20

2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE Structure
2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE structure
Common Name 2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE
CAS Number 56005-10-8 Molecular Weight 308.41300
Density 1.06g/cm3 Boiling Point 439.5ºC at 760mmHg
Molecular Formula C18H28O4 Melting Point N/A
MSDS N/A Flash Point 149.9ºC

 Use of 2-HYDROXY-5-METHOXY-3-UNDECYL[1,4]BENZOQUINONE


5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].

 Names

Name 5-O-methyl embelin
Synonym More Synonyms

  Biological Activity

Description 5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
Related Catalog
In Vitro 5-O-Methylembelin(compound 3;20 μM;24 小时)显着下调 PCSK9(IC50 值为 4.9 μM)、IDOL 和 SREBP2 mRNA 表达[1]。 RT-PCR[1] Cell Line: HepG2 cells Concentration: 20 μM Incubation Time: 24 h Result: Inhibited PCSK9, IDOL, and SREBP2 mRNA expression.
References

[1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305.  

 Chemical & Physical Properties

Density 1.06g/cm3
Boiling Point 439.5ºC at 760mmHg
Molecular Formula C18H28O4
Molecular Weight 308.41300
Flash Point 149.9ºC
Exact Mass 308.19900
PSA 63.60000
LogP 4.40150
Index of Refraction 1.505

 Safety Information

HS Code 2914690090

 Customs

HS Code 2914690090
Summary 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

5-O-Methylembelin
2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione