6-Aminopenicillanic acid

Modify Date: 2024-01-02 11:47:56

6-Aminopenicillanic acid structure	Common Name	6-Aminopenicillanic acid
	CAS Number	551-16-6	Molecular Weight	216.258
	Density	1.5±0.1 g/cm3	Boiling Point	460.2±45.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₂N₂O₃S	Melting Point	198-200 °C (dec.)(lit.)
	MSDS	USA	Flash Point	232.1±28.7 °C

Use of 6-Aminopenicillanic acid

6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA)[1].

Name	6-aminopenicillanic acid
Synonym	More Synonyms

Description	6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Lucie Vobecká, et al. Optimization of Aqueous Two-Phase Systems for the Production of 6-aminopenicillanic Acid in Integrated Microfluidic Reactors-Separators. N Biotechnol. 2018 Dec 25;47:73-79.

Density	1.5±0.1 g/cm3
Boiling Point	460.2±45.0 °C at 760 mmHg
Melting Point	198-200 °C (dec.)(lit.)
Molecular Formula	C₈H₁₂N₂O₃S
Molecular Weight	216.258
Flash Point	232.1±28.7 °C
Exact Mass	216.056870
PSA	108.93000
LogP	-0.36
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.656
Storage condition	2~8°C

6-Aminopenicillanic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH8225000

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-amino-3,3-dimethyl-7-oxo-

CAS REGISTRY NUMBER :: 551-16-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H12-N2-O3-S

MOLECULAR WEIGHT :: 216.28

WISWESSER LINE NOTATION :: T45 ANV ESTJ CZ F1 F1 GVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg/65W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 19,392,1965 *** REVIEWS *** TOXICOLOGY REVIEW 22HAAD "Microbial Toxins, 1970-72," Ajil, S.J., et al., eds., New York, Academic Press, Inc., 1970-72 Volume(issue)/page/year: 6,409,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.4 mg/m3;Skin JAN 1993

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R42/43
Safety Phrases	S22-S36/37-S45-S37-S24
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	XH8225000
HS Code	2941109300

Precursor 5
CAS#:87-08-1 Penicillin-V CAS#:20425-27-8 (2S,5R,6R)-6-(1... CAS#:128971-96-0 (2S,5R,6S)-Benz... CAS#:128971-92-6 (3S,4R)-3-[(ter...
CAS#:128971-93-7 (3S,4R)-3-[(ter...
DownStream 10
CAS#:37091-66-0 Azlocillin CAS#:32887-01-7 Mecillinam CAS#:14796-35-1 2-(2'-carboxyph... CAS#:19379-33-0 L-(+)-Ampicillin
CAS#:69-53-4 Ampicillin CAS#:2935-35-5 H-Phg-OH CAS#:205320-24-7 (2S)-6,6-dibrom... CAS#:2315-05-1 methyl 3,3-dime...
CAS#:343-55-5 Dicloxacillin Sodium CAS#:61-33-6 Penicillin-G

HS Code	2941109300
Summary	2941109300. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:Q(report of inspection of soundness on import medicines). MFN tariff:4.0%. General tariff:20.0%

Enhanced production of 6-aminopenicillanic acid in aqueous methyl isobutyl ketone system with immobilized penicillin G acylase.

Prep Biochem Biotechnol. 40(1) , 38-45, (2010)

Enzymatic hydrolysis of penicillin G for production of 6-amino-penicillanic-acid (6-APA) was achieved by using penicillin G acylase as catalyst in an aqueous-methylisobutyl ketone (MIBK) system. The o...

Monitoring bioreactors using principal component analysis: production of penicillin G acylase as a case study.

Bioprocess Biosyst. Eng. 33(5) , 557-64, (2010)

The complexity of biological processes often makes impractical the development of detailed, structured phenomenological models of the cultivation of microorganisms in bioreactors. In this context, dat...

Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase.

Bioorg. Med. Chem. Lett. 19(14) , 3787-90, (2009)

We report the first synthesis of a 5S penem, known to bind bacterial type I signal peptidase, from the commercially available and inexpensive 6-aminopenicillanic acid. We report the first in vivo acti...

[2S-(2a,5a,6b)]-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

EINECS 208-993-4

6-aps

6-AMINO PENICILLINIC ACID

6-Aminopenicillanic acid

penicin

6-Aminopenicillansure

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-amino-3,3-dimethyl-7-oxo-, (2S,5R,6R)-

aminopenicillanicacid

MFCD00005176

6-APA

6b-Aminopenicillanic Acid

(2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Amoxicillin Impurity 1

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 6-Aminopenicillanic acid
Price: ￥348.0/100g ￥118.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 6-Aminopenicillanic acid
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-Aminopenicillanic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 6-aminopenicillanic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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6-Aminopenicillanic acid

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