(E)-Ferulic acid

Modify Date: 2024-01-02 18:28:06

(E)-Ferulic acid Structure
(E)-Ferulic acid structure
Common Name (E)-Ferulic acid
CAS Number 537-98-4 Molecular Weight 194.184
Density 1.3±0.1 g/cm3 Boiling Point 372.3±27.0 °C at 760 mmHg
Molecular Formula C10H10O4 Melting Point 168-172ºC
MSDS Chinese USA Flash Point 150.5±17.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of (E)-Ferulic acid


(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

 Names

Name Trans-Ferulic Acid
Synonym More Synonyms

 (E)-Ferulic acid Biological Activity

Description (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
Related Catalog
Target

Bax

References

[1]. Fong Y, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016 Oct 1;11:45.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 372.3±27.0 °C at 760 mmHg
Melting Point 168-172ºC
Molecular Formula C10H10O4
Molecular Weight 194.184
Flash Point 150.5±17.2 °C
Exact Mass 194.057907
PSA 66.76000
LogP 1.64
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.627
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD9275000
CHEMICAL NAME :
Cinnamic acid, 4-hydroxy-3-methoxy-, (E)-
CAS REGISTRY NUMBER :
537-98-4
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H10-O4
MOLECULAR WEIGHT :
194.20
WISWESSER LINE NOTATION :
QV1U1R DQ CO1 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>194 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
9600 mg/kg
SEX/DURATION :
female 12 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
25 gm/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UD3365500

 Articles234

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 Synonyms

Coniferic acid
(E)-4-Hydroxy-3-methoxycinnamic acid
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
Metronidazole Benzoate
trans-4-Hydroxy-3-methoxycinnamic acid,trans-Ferulic acid,Ferulic acid
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
Ferulic acid, trans-
3-(4-Hydroxy-3-methoxyphenyl)propenoic acid
(2E)-3-(4-Hydroxy-3-methoxyphenyl)acrylic acid
1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, benzoate (ester)
MFCD00004400
trans-4-Hydroxy-3-methoxycinnamic acid,Ferulic acid
Ferulic acid, E-
(E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid
caffeic acid 3-methyl ether
Benzoylmetronildazole
(E)-4-hydroxy-3-methoxy-Cinnamic acid
(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Trans-4-Hydroxy-3-methoxycinnamic acid
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
2-Methyl-5-nitro-1H-imidazole-1-ethyl benzoate
Ferulic acid
trans-Ferulic acid
EINECS 208-679-7
2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl benzoate
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