Euxanthone

Modify Date: 2024-01-02 14:58:41

Euxanthone Structure
Euxanthone structure
 Common Name Euxanthone
CAS Number 529-61-3 Molecular Weight 228.200
Density 1.5±0.1 g/cm3 Boiling Point 472.6±45.0 °C at 760 mmHg
Molecular Formula C13H8O4 Melting Point N/A
MSDS N/A Flash Point 191.1±22.2 °C

 Use of Euxanthone


Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

 Names

Name euxanthone
Synonym More Synonyms

 Euxanthone Biological Activity

Description Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].
Related Catalog
In Vitro Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。 Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Inhibited cell migration at 24 hr. Western Blot Analysis[1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
In Vivo 在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] Dosage: 30 mg/kg, 60 mg/kg Administration: p.o.;once a day; for 7 days Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
References

[1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408.  

[2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455.  

[3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 472.6±45.0 °C at 760 mmHg
Molecular Formula C13H8O4
Molecular Weight 228.200
Flash Point 191.1±22.2 °C
Exact Mass 228.042252
PSA 70.67000
LogP 1.92
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.718

 Safety Information

HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1,7-Dihydroxy-9H-xanthen-9-one
1,7-dihydroxyxanthen-9-one
purrenone
1,7-Dihydroxyxanthone
eyxanthone
Euxanthone
1,7-Dihydroxy-xanthen-9-on
1,7-dihydroxy-xanthen-9-one
9H-Xanthen-9-one, 1,7-dihydroxy-
Top Suppliers:I want be here
  • BioBioPha
  • China
  • Product Name: Euxanthone
  • Price: ￥2500.0/5mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng

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Price: ￥5616/5mg

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Related Compounds: More...
Euxanthone-7-O-glucopyranoside
96935-32-9
Chemsrc provides Euxanthone(CAS#:529-61-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Euxanthone are included as well.>> amp version: Euxanthone

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