dihydroquinine

Modify Date: 2024-01-05 13:34:25

dihydroquinine Structure
dihydroquinine structure
Common Name dihydroquinine
CAS Number 522-66-7 Molecular Weight 326.433
Density 1.2±0.1 g/cm3 Boiling Point 498.4±30.0 °C at 760 mmHg
Molecular Formula C20H26N2O2 Melting Point 168-176ºC(lit.)
MSDS Chinese USA Flash Point 255.2±24.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of dihydroquinine


Hydroquinone is a inhibitor of melanin synthesis, serves as a skin whitener and is usually available in cosmetics or on prescription[1].Hydroquinone can be used in the preparation of oxidized light-emitting materials such as lucigenin by inducing the production of hydrogen peroxide in the presence of basic compounds.Hydroquinone (HQ) is the most abundant quinine present in cigarette tar it can enter the circulation via the lungs and can interact with cellular targets throughout the body, hepatotoxic and nephrotoxic properties has been reported[1].

 Names

Name hydroquinine
Synonym More Synonyms

 dihydroquinine Biological Activity

Description Hydroquinone is a inhibitor of melanin synthesis, serves as a skin whitener and is usually available in cosmetics or on prescription[1].Hydroquinone can be used in the preparation of oxidized light-emitting materials such as lucigenin by inducing the production of hydrogen peroxide in the presence of basic compounds.Hydroquinone (HQ) is the most abundant quinine present in cigarette tar it can enter the circulation via the lungs and can interact with cellular targets throughout the body, hepatotoxic and nephrotoxic properties has been reported[1].
Related Catalog
References

[1]. Sharma A, et al. Effects of hydroquinone on retinal and vascular cells in vitro. Indian J Ophthalmol. 2012 May-Jun;60(3):189-93.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 498.4±30.0 °C at 760 mmHg
Melting Point 168-176ºC(lit.)
Molecular Formula C20H26N2O2
Molecular Weight 326.433
Flash Point 255.2±24.6 °C
Exact Mass 326.199432
PSA 45.59000
LogP 3.77
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.626
Storage condition 2~8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR UN 1544
WGK Germany 3
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090

 Synthetic Route

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Hoffmann-La Roche Inc. Patent: US3931192 A1, 1976 ;

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Boehringer and Soehne Patent: DE306939 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 839,840 Full Text Show Details Boehringer and Soehne Patent: DE307894 ;

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Paal; Amberger Patent: DE346949 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 1468

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Giemsa; Bonath Chemische Berichte, 1925 , vol. 58, p. 95 Full Text Show Details Giemsa; Halberkann Chemische Berichte, 1918 , vol. 51, p. 1330

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Giemsa; Bonath Chemische Berichte, 1925 , vol. 58, p. 95 Full Text Show Details Giemsa; Halberkann Chemische Berichte, 1918 , vol. 51, p. 1330

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Giemsa; Halberkann Chemische Berichte, 1918 , vol. 51, p. 1330

~%

dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Henry et al. Journal of the Chemical Society, 1937 , p. 592,600 Journal of the Chemical Society, 1935 , p. 966,967

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dihydroquinine Structure

dihydroquinine

CAS#:522-66-7

Literature: Henry et al. Journal of the Chemical Society, 1937 , p. 592,600 Journal of the Chemical Society, 1935 , p. 966,967

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles26

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Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012)

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and ...

Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).

J. Org. Chem. 77(16) , 7076-80, (2012)

A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic sy...

Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 65(2) , 333-9, (2006)

Geometric parameters, the vibrational frequencies and thermochemical values of benzoquinone and hydroquinone were computed using ab initio molecular orbital calculations (HF) and density function theo...

 Synonyms

Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (8α,9R)-
(1R)-((2S,4S,5R)-5-Ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol
(8α,9R)-6'-Methoxy-10,11-dihydrocinchonan-9-ol
Quinine,10,11-dihydro
10,11-Dihydroquinine
HYDROQUININE
(8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol
Hydroquinine,Dihydroquinine
(-)-Dihydroquinine
dihydroquinine
dihydro quinine