Pamidronic acid

Modify Date: 2024-01-02 14:46:57

Pamidronic acid structure	Common Name	Pamidronic acid
	CAS Number	40391-99-9	Molecular Weight	235.06900
	Density	1.998 g/cm3	Boiling Point	658.7ºC at 760 mmHg
	Molecular Formula	C₃H₁₁NO₇P₂	Melting Point	226-228ºC
	MSDS	N/A	Flash Point	352.2ºC

Use of Pamidronic acid

Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.

Name	Pamidronic acid
Synonym	More Synonyms

Description	Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> β-catenin Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Wnt, β-catenin[1]
In Vitro	Osteosarcoma cell viability decreases significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 μM, most consistently after 48 and 72 hours' exposure. In treated osteosarcoma cells, the lowest percentage cell viability is 34% (detected after 72 hours' exposure to 1000μM pamidronate)[1]. Pamidronate disodium inhibits Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reverses the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs[2].
In Vivo	Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression[3].
Cell Assay	Cell counts and cell viability assays are performed in cultures of osteosarcoma cells (POS, HMPOS, and COS31 cell lines) and fibroblasts after 24, 48, and 72 hours of incubation with pamidronate at concentrations of 0.001 to 1000 microM or with no drug (control treatment). Percentage viability is determined in cell samples for each concentration of pamidronate and each incubation time. A DNA fragmentation analysis is performed to assess bisphosphonate-induced apoptosis[1].
Animal Admin	Rabbits: The rabbits are randomly divided into four groups. Sham-operated with vehicle treatment, OA induced by ACLT with vehicle treatment, OA-induced ACLT treated with short-term pamidronic acid treatment after ACLT, and ACLT treated with long-term PAM treatment. PAM is injected at the 4th week after ACLT in PAM-S and PAM-L groups, and followed by once monthly ear vein injections at a dosage of 3 mg/kg body weight. In the other groups, only saline infusions of equal volumes are administered. 10 animals are humanely sacrificed at both 2 and 10 weeks after pamidronic acid treatment. In the ACLT and Sham groups, five animals are sacrificed at 2, 4, 6, and 14 weeks after model establishment[3].
References	[1]. Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91. [2]. Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22. [3]. Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370.

Density	1.998 g/cm3
Boiling Point	658.7ºC at 760 mmHg
Melting Point	226-228ºC
Molecular Formula	C₃H₁₁NO₇P₂
Molecular Weight	235.06900
Flash Point	352.2ºC
Exact Mass	235.00100
PSA	180.93000
Index of Refraction	1.611
Storage condition	2-8℃

beta-Alanine structure

beta-Alanine

CAS#:107-95-9

~76%

Pamidronic acid Structure

Pamidronic acid

CAS#:40391-99-9

Literature: Yanvarev; Korovina; Usanov; Kochetkov Russian Journal of Bioorganic Chemistry, 2012 , vol. 38, # 2 p. 224 - 229

[3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid structure

[3-(benzyloxyca...

CAS#:948317-73-5

~92%

Pamidronic acid Structure

Pamidronic acid

CAS#:40391-99-9

Literature: Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391

[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-phosphonopropyl]phosphonic acid structure

[3-(1,3-dioxo-1...

CAS#:917092-03-6

~69%

Pamidronic acid Structure

Pamidronic acid

CAS#:40391-99-9

Literature: Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc European Journal of Organic Chemistry, 2007 , # 20 p. 3380 - 3391

Precursor 1
CAS#:107-95-9 beta-Alanine
DownStream 1
CAS#:63132-39-8 Me2-APD

Pamidronic Acid See P172500

Pamidronic Acid

EINECS 254-905-2

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pamidronic acid
Price: ￥1876.0/1g ￥8296.0/10g ￥746.0/250mg ￥5256.0/5g
Purity: 95.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Pamidronic acid
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pamidronic Acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥575/250mg

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