Gelsevirine

Modify Date: 2024-01-09 19:16:29

Gelsevirine structure	Common Name	Gelsevirine
	CAS Number	38990-03-3	Molecular Weight	352.427
	Density	1.3±0.1 g/cm3	Boiling Point	456.6±55.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₄N₂O₃	Melting Point	245 °C
	MSDS	N/A	Flash Point	229.9±31.5 °C

Use of Gelsevirine

Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively[1][2][3].

Name	(1'R,3S,5'S,6'S,8'S)-1-Methoxy-4'-methyl-2'-vinylspiro[indole-3,7'-[9]oxa[4]azatetracyclo[6.3.1.02,6.05,11]dodecan]-2(1H)-one
Synonym	More Synonyms

Description	Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Hua-Hai Zhang, et al. Characterization of Gelsevirine Metabolites in Rat Liver S9 by Accurate Mass Measurements Using High-Performance Liquid chromatography/quadrupole-time-of-flight Mass Spectrometry. Rapid Commun Mass Spectrom. 2019 Jul 30;33(14):1179-1184. [2]. Ming Liu, et al. The Active Alkaloids of Gelsemium Elegans Benth. Are Potent Anxiolytics. Psychopharmacology (Berl). 2013 Feb;225(4):839-51. [3]. HUANG Jing, et al. Cytotoxic effects of alkaloidal compounds from Gelsemium elegans Benth on the tumor cells of digestive system in vitro. Strait Pharmaceutical Journal, 2010 , 22 (3) :197-200.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Hua-Hai Zhang, et al. Characterization of Gelsevirine Metabolites in Rat Liver S9 by Accurate Mass Measurements Using High-Performance Liquid chromatography/quadrupole-time-of-flight Mass Spectrometry. Rapid Commun Mass Spectrom. 2019 Jul 30;33(14):1179-1184.

[2]. Ming Liu, et al. The Active Alkaloids of Gelsemium Elegans Benth. Are Potent Anxiolytics. Psychopharmacology (Berl). 2013 Feb;225(4):839-51.

[3]. HUANG Jing, et al. Cytotoxic effects of alkaloidal compounds from Gelsemium elegans Benth on the tumor cells of digestive system in vitro. Strait Pharmaceutical Journal, 2010 , 22 (3) :197-200.

Density	1.3±0.1 g/cm3
Boiling Point	456.6±55.0 °C at 760 mmHg
Melting Point	245 °C
Molecular Formula	C₂₁H₂₄N₂O₃
Molecular Weight	352.427
Flash Point	229.9±31.5 °C
Exact Mass	352.178680
PSA	42.01000
LogP	2.74
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.662

Hazard Codes	Xi

(1'R,2'S,3S,5'S,6'S,8'R,11'S)-1-Methoxy-4'-methyl-2'-vinylspiro[indole-3,7'-[9]oxa[4]azatetracyclo[6.3.1.0.0]dodecan]-2(1H)-one

(1'R,3S,5'S,6'S,8'S)-1-Methoxy-4'-methyl-2'-vinylspiro[indole-3,7'-[9]oxa[4]azatetracyclo[6.3.1.0.0]dodecan]-2(1H)-one

BioBioPha
China
Product Name: Gelsevirine
Price: ￥1650.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gelsevirine
Price: ￥4800.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: GELSEVIRINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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