Apramycin

Modify Date: 2024-01-11 12:07:17

Apramycin structure	Common Name	Apramycin
	CAS Number	37321-09-8	Molecular Weight	539.57700
	Density	1.56 g/cm3	Boiling Point	823ºC at 760 mmHg
	Molecular Formula	C₂₁H₄₁N₅O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	451.6ºC

Use of Apramycin

Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.

Name	apramycin
Synonym	More Synonyms

Description	Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Apramycin, From Wikipedia

Density	1.56 g/cm3
Boiling Point	823ºC at 760 mmHg
Molecular Formula	C₂₁H₄₁N₅O₁₁
Molecular Weight	539.57700
Flash Point	451.6ºC
Exact Mass	539.28000
PSA	283.64000
Index of Refraction	1.657

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK1970000

CAS REGISTRY NUMBER :: 37321-09-8

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H41-N5-O11

MOLECULAR WEIGHT :: 539.67

WISWESSER LINE NOTATION :: T66 BO GOTJ DM1 EQ IZ CO- BT6OTJ CQ DQ EZ F1Q& HO- BL6TJ AZ CQ DQ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977

APRAMYCIN

el857

EINECS 253-460-1

nebramycinfactor2

el-857/820

apralan

ApryMycin

ambylan

DC Chemicals Limited
China
Product Name: Apramycin
Price: $400.0/10mg $1200.0/50mg $1680.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $60/50mg

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Apramycin

Use of Apramycin

Names

Apramycin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms