blasticidin s hydrochloride

Modify Date: 2024-01-08 11:18:29

blasticidin s hydrochloride structure	Common Name	blasticidin s hydrochloride
	CAS Number	3513-03-9	Molecular Weight	458.90
	Density	N/A	Boiling Point	772.1ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₇ClN₈O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	420.8ºC
	Symbol	GHS06	Signal Word	Danger

Use of blasticidin s hydrochloride

Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells[1].

Name	(2S,3S,6R)-3-[[(3R)-3-amino-5-[carbamimidoyl(methyl)amino]pentanoyl]amino]-6-(4-amino-2-oxopyrimidin-1-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid,hydrochloride
Synonym	More Synonyms

Description	Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Blasticidin S (BlaS) is a broad spectrum antibiotic and inhibits cell growth in prokaryotes, fungi, plants, and mammalian cells[1].
References	[1]. Kitamura K, et al. Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):393-398.

Boiling Point	772.1ºC at 760 mmHg
Molecular Formula	C₁₇H₂₇ClN₈O₅
Molecular Weight	458.90
Flash Point	420.8ºC
Exact Mass	458.17900
PSA	215.67000
LogP	1.05570
Storage condition	−20°C
Water Solubility	Soluble in water. Insoluble in organic solvents.

blasticidin s hydrochloride MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R28
Safety Phrases	28-36/37-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3

A rice fungicide blasticidin S efficiently binds Cu(II) ions and prevents DNA from metal-induced damage.

J. Inorg. Biochem. 127 , 73-8, (2013)

Blasticidin S is a representative of the aminoacylnucleoside class of antibiotics and it possesses fungicidal properties against the virulent fungus which causes a serious rice blast disease in Asia. ...

Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome.

Proc. Natl. Acad. Sci. U. S. A. 110(30) , 12283-8, (2013)

The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and...

Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.

Proc. Natl. Acad. Sci. U. S. A. 103 , 13485-13490, (2006)

Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and rel...

MFCD02091640

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Blasticidin S hydrochloride