UK 383367

Modify Date: 2024-01-02 17:28:59

UK 383367 structure	Common Name	UK 383367
	CAS Number	348622-88-8	Molecular Weight	324.375
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₅H₂₄N₄O₄	Melting Point	136-138℃
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of UK 383367

UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent

Name	5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
Synonym	More Synonyms

Description	UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Procollagen C Proteinase Research Areas >> Others
References	[1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418. [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Procollagen C Proteinase

Research Areas >> Others

References

[1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418.

[2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562.

Density	1.2±0.1 g/cm3
Melting Point	136-138℃
Molecular Formula	C₁₅H₂₄N₄O₄
Molecular Weight	324.375
Exact Mass	324.179749
PSA	134.83000
LogP	1.37
Appearance of Characters	white to off-white
Index of Refraction	1.541
Storage condition	Store at -20°C
Water Solubility	DMSO: >30mg/mL

UK 383367 MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	Xn
Risk Phrases	22
RIDADR	UN 2811 6.1 / PGIII

CS-0414

UK383367

1,2,4-Oxadiazole-5-propanamide, 3-(aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-, (βR)-

S2224_Selleck

5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide

UK 383367

5-[(3R)-6-Cyclohexyl-1-(hydroxyamino)-1-oxo-3-hexanyl]-1,2,4-oxadiazole-3-carboxamide

UK-383367

DC Chemicals Limited
China
Product Name: UK-383367
Price: $900.0/100mg $1800.0/250mg $3600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $60/5mg

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UK 383367

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