H-D-Leu-OH

Modify Date: 2024-01-02 10:10:08

H-D-Leu-OH Structure
H-D-Leu-OH structure
 Common Name H-D-Leu-OH
CAS Number 328-38-1 Molecular Weight 131.173
Density 1.0±0.1 g/cm3 Boiling Point 225.8±23.0 °C at 760 mmHg
Molecular Formula C6H13NO2 Melting Point > 300ºC
MSDS Chinese USA Flash Point 90.3±22.6 °C

 Use of H-D-Leu-OH


D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

 Names

Name D-leucine
Synonym More Synonyms

 H-D-Leu-OH Biological Activity

Description D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Related Catalog
Target

Human Endogenous Metabolite
In Vitro In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].
References

[1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 225.8±23.0 °C at 760 mmHg
Melting Point > 300ºC
Molecular Formula C6H13NO2
Molecular Weight 131.173
Flash Point 90.3±22.6 °C
Exact Mass 131.094635
PSA 63.32000
LogP 0.73
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.463

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OH2840000
CHEMICAL NAME :
Leucine, D-
CAS REGISTRY NUMBER :
328-38-1
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H13-N-O2
MOLECULAR WEIGHT :
131.20
WISWESSER LINE NOTATION :
QVYZ1Y1&1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6429 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 22-24/25-36-26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS OH2840000
HS Code 2922499990

 Synthetic Route

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles4

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Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.

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Potent anti-seizure effects of D-leucine.

Neurobiol. Dis. 82 , 46-53, (2015)

There are no effective treatments for millions of patients with intractable epilepsy. High-fat ketogenic diets may provide significant clinical benefit but are challenging to implement. Low carbohydra...

 Synonyms

leucine
D-Leucine
MFCD00063088
(R)-2-Amino-4-methylpentanoic acid
(2R)-2-amino-4-methylpentanoic acid
ent-1
H-Leu-OH
D-Homo-valine
D-2-Amino-4-methylvaleric acid
H-D-Leu-OH
(R)-2-Amino-4-methyl-pentanoic acid
Leucine, D-
EINECS 206-327-7
D-2-Amino-4-methylpentanoicacid
Top Suppliers:I want be here
  • DC Chemicals Limited
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  • Product Name: D-Leucine
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  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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H-D-Leu-OH price

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