2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Modify Date: 2024-01-02 16:50:19

2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide structure	Common Name	2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide
	CAS Number	322-35-0	Molecular Weight	257.24300
	Density	1.541 g/cm3	Boiling Point	574.2ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₅N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	301ºC

Use of 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1].

Name	benserazide
Synonym	More Synonyms

Description	Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151.

Density	1.541 g/cm3
Boiling Point	574.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅N₃O₅
Molecular Weight	257.24300
Flash Point	301ºC
Exact Mass	257.10100
PSA	148.07000
Index of Refraction	1.678

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT9632200

CHEMICAL NAME :: Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-

CAS REGISTRY NUMBER :: 322-35-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H15-N3-O5

MOLECULAR WEIGHT :: 257.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23400 mg/kg/90D-C

TOXIC EFFECTS :: Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2880 mg/kg

SEX/DURATION :: female 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26
HS Code	2928000090

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

bensarazide

Benseraszide

Ro 4-4602

Benserazida

DL-Seryltrihydroxybenzylhydrazine

MFCD00242633

2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide

Serazide

Benserazidum

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Use of 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

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