sevoflurane

Modify Date: 2024-01-02 15:46:10

sevoflurane structure	Common Name	sevoflurane
	CAS Number	28523-86-6	Molecular Weight	200.055
	Density	1.4±0.1 g/cm3	Boiling Point	49.5±35.0 °C at 760 mmHg
	Molecular Formula	C₄H₃F₇O	Melting Point	50-60ºC
	MSDS	Chinese USA	Flash Point	-11.4±21.8 °C
	Symbol	GHS07	Signal Word	Warning

Name	sevoflurane
Synonym	More Synonyms

Density	1.4±0.1 g/cm3
Boiling Point	49.5±35.0 °C at 760 mmHg
Melting Point	50-60ºC
Molecular Formula	C₄H₃F₇O
Molecular Weight	200.055
Flash Point	-11.4±21.8 °C
Exact Mass	200.007217
PSA	9.23000
LogP	2.48
Vapour Pressure	311.5±0.1 mmHg at 25°C
Index of Refraction	1.266

sevoflurane MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KO0737000

CHEMICAL NAME :: Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-

CAS REGISTRY NUMBER :: 28523-86-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H3-F7-O

MOLECULAR WEIGHT :: 200.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28800 ppm/3H

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5497,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28300 ppm/3H

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5497,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 6600 ppm/3H

SEX/DURATION :: male 64 day(s) pre-mating female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 2 pph/3H

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 pph/3H

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	UN 3334
RTECS	KO0737000

Precursor 9
CAS#:26103-07-1 Chloromethyl-1,... CAS#:373-53-5 Fluor(iod)methan CAS#:920-66-1 Hexafluoroisopr... CAS#:373-52-4 Bromofluoromethane
CAS#:593-70-4 Chlorofluoromethane CAS#:406-58-6 1,1,1,3,3-Penta... CAS#:50-00-0 Formaldehyde CAS#:1152045-94-7 methyl 3,3,3-tr...
CAS#:97614-43-2 2-Deoxy-2-fluor...
DownStream 3
CAS#:26103-07-1 Chloromethyl-1,... CAS#:13171-18-1 Hexafluoroisopr... CAS#:58109-34-5 1,1,3,3,3-Penta...

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Sevoness

Sevofrane

R-E 347

mr6s4

Fluoromethyl 1,1,1,3,3,3-hexafluoropropan-2-yl ether

347mmzEbg

fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether

Ultane

oxyde de fluorométhyle et de 2,2,2-trifluoro-1-(trifluorométhyl)éthyle

Sevoflurane

Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-

Sevorane

1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane

Fluormethyl-2,2,2-trifluor-1-(trifluormethyl)ethylether

Fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether

MFCD00153189

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: sevoflurane
Price: ￥2108.0/5g ￥658.0/1g ￥3508.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sevoflurane
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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sevoflurane

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