Beta-Elemonic acid

Modify Date: 2024-01-07 19:39:32

Beta-Elemonic acid Structure
Beta-Elemonic acid structure
Common Name Beta-Elemonic acid
CAS Number 28282-25-9 Molecular Weight 454.684
Density 1.07 Boiling Point 565.2±50.0 °C at 760 mmHg
Molecular Formula C30H46O3 Melting Point 216-219 ºC
MSDS Chinese USA Flash Point 309.6±26.6 °C

 Use of Beta-Elemonic acid


β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].

 Names

Name β-Elemonic acid
Synonym More Synonyms

 Beta-Elemonic acid Biological Activity

Description β-Elemonic acid is a triterpene isolated from Boswellia papyrifera. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects[1][2].
Related Catalog
Target

COX-2

In Vitro β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner[1]. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC50 value following a 24-h exposure to β-elemonic acid was 6.92 µM[1]. β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase[1]. β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells[1].
References

[1]. Atta-ur-Rahman, et al. Bioactive constituents from Boswellia papyrifera. J Nat Prod. 2005 Feb;68(2):189-93.

[2]. Wu TT, et al. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The roleof MAPK, ROS activation and glutathione depletion. Oncol Rep. 2016 Jan;35(1):227-34.

 Chemical & Physical Properties

Density 1.07
Boiling Point 565.2±50.0 °C at 760 mmHg
Melting Point 216-219 ºC
Molecular Formula C30H46O3
Molecular Weight 454.684
Flash Point 309.6±26.6 °C
Exact Mass 454.344696
PSA 54.37000
LogP 8.56
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.542
Storage condition -20℃

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

(5β,13α,14β,20S)-3-Oxolanosta-8,24-dien-21-oic acid
Lanosta-8,24-dien-21-oic acid, 3-oxo-, (5β,13α,14β,20S)-
(2S)-6-methyl-2-[(10S,14S,17S)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,7,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hept-5-enoic acid
beta-Elemonic acid