NH 125
Modify Date: 2024-01-16 12:24:41
NH 125 structure
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Common Name | NH 125 | ||
|---|---|---|---|---|
| CAS Number | 278603-08-0 | Molecular Weight | 524.564 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H45IN2 | Melting Point | 88.2-94.9ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of NH 125NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also could induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K. |
| Name | 1-benzyl-3-hexadecyl-2-methylimidazol-1-ium,iodide |
|---|---|
| Synonym | More Synonyms |
| Description | NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also could induce eEF2 phosphorylation, with an IC50 of 60 nM for eEF-2K. |
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| Related Catalog | |
| Target |
eEF-2K:60 nM (IC50) |
| In Vitro | NH125 inhibits eEF-2 kinase activity (IC50 = 60 nM) in vitro, blocks the phosphorylation of eEF-2 in intact cells, and shows relative selectivity over other protein kinases: protein kinase C (IC50 = 7.5 μM), protein kinase A (IC50 = 80 μM), and calmodulin-dependent kinase II (IC50 > 100 μM). NH125 decreases the viability of 10 cancer cell lines with IC50s ranging from 0.7 to 4.7 μM. Forced overexpression of eEF-2 kinase in a glioma cell line produces 10-fold resistance to NH125. In conclusion, these results suggest that identification of potent inhibitors of eEF-2 kinase may lead to the development of new types of anticancer drugs[1]. Anticancer effect of NH125 is not mediated through inhibition of eEF2K. Inhibition of cell growth correlates with induction of peEF2[2]. |
| References |
| Melting Point | 88.2-94.9ºC |
|---|---|
| Molecular Formula | C27H45IN2 |
| Molecular Weight | 524.564 |
| Exact Mass | 524.262756 |
| PSA | 8.81000 |
| LogP | 4.61760 |
| Appearance of Characters | solid | white to off-white |
| Storage condition | −20°C |
| Water Solubility | DMSO: 20 mg/mL |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β.
J. Neurosci. 34(36) , 12230-8, (2014) The AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that is activated in response to low-energy states to coordinate multiple signaling pathways to maintain cellular energy homeostasis. Dysreg... |
| 1-Benzyl-3-cetyl-2-methylimidazolium iodide |
| NH125 |
| 1H-Imidazolium, 1-hexadecyl-2-methyl-3-(phenylmethyl)-, iodide (1:1) |
| eEF-2 Kinase Inhibitor,NH125 |
| HMS3229F01 |
| 3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide |