Triapine structure
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Common Name | Triapine | ||
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CAS Number | 200933-27-3 | Molecular Weight | 195.245 | |
Density | 1.46 | Boiling Point | 436.0±55.0 °C at 760 mmHg | |
Molecular Formula | C7H9N5S | Melting Point | N/A | |
MSDS | N/A | Flash Point | 217.5±31.5 °C |
Use of Triapine(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2]. |
Name | (2E)-2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide |
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Synonym | More Synonyms |
Description | (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2]. |
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Related Catalog | |
In Vitro | 3-AP shows anti-proliferative activity with IC50 values of 1.3, 1.6 µM for L1210, L1210/HUr cells, respectively[1]. 3-AP (5, 10, 15, 20, 30 mg/kg; i.p.; twice daily for six consecutive days) significantly increases in life span were observed with each dosage employed and long term survivors[1]. |
References |
Density | 1.46 |
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Boiling Point | 436.0±55.0 °C at 760 mmHg |
Molecular Formula | C7H9N5S |
Molecular Weight | 195.245 |
Flash Point | 217.5±31.5 °C |
Exact Mass | 195.057861 |
PSA | 125.95000 |
LogP | 0.98 |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.720 |
Storage condition | -20℃ |
2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide |
2-[(3-Aminopyridin-2-yl)methylene]hydrazinecarbothioamide |
Triapine |
Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]- |
2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide |