Tubulysin

Modify Date: 2024-01-07 22:13:50

Tubulysin structure	Common Name	Tubulysin
	CAS Number	1943604-24-7	Molecular Weight	842.10
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₄H₆₇N₅O₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tubulysin

Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].

Name	Tubulysin

Description	Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.

Molecular Formula	C₄₄H₆₇N₅O₉S
Molecular Weight	842.10

Tubulysin

Use of Tubulysin

Names

Tubulysin Biological Activity

Chemical & Physical Properties