dehydroabietic acid

Modify Date: 2024-01-02 18:43:24

dehydroabietic acid Structure
dehydroabietic acid structure
Common Name dehydroabietic acid
CAS Number 1740-19-8 Molecular Weight 300.435
Density 1.1±0.1 g/cm3 Boiling Point 425.1±34.0 °C at 760 mmHg
Molecular Formula C20H28O2 Melting Point 174-176ºC
MSDS Chinese USA Flash Point 202.5±20.3 °C
Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger

 Use of dehydroabietic acid


Dehydroabietic acid possesses antiviral activity[1].

 Names

Name dehydroabietic acid
Synonym More Synonyms

 dehydroabietic acid Biological Activity

Description Dehydroabietic acid possesses antiviral activity[1].
Related Catalog
References

[1]. Fonseca T, et al. Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid. Bioorg Med Chem. 2004 Jan 2;12(1):103-12.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 425.1±34.0 °C at 760 mmHg
Melting Point 174-176ºC
Molecular Formula C20H28O2
Molecular Weight 300.435
Flash Point 202.5±20.3 °C
Exact Mass 300.208923
PSA 37.30000
LogP 6.35
Appearance of Characters NA
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.540
Storage condition ?20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP8710000
CHEMICAL NAME :
Podocarpa-8,11,13-trien-15-oic acid, 13-isopropyl-
CAS REGISTRY NUMBER :
1740-19-8
BEILSTEIN REFERENCE NO. :
2059290
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C20-H28-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1710 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 18,42,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8400 mg/kg/28D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 18,42,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2653 No. of Facilities: 1630 (estimated) No. of Industries: 16 No. of Occupations: 20 No. of Employees: 13811 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2653 No. of Facilities: 394 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 14625 (estimated) No. of Female Employees: 4688 (estimated)

 Safety Information

Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger
Hazard Statements H301-H410
Precautionary Statements P273-P301 + P310-P501
Hazard Codes T,N
Risk Phrases 25-50
Safety Phrases 45-61
RIDADR UN 2811 6.1 / PGIII

 Articles42

More Articles
Development of ultrasonic-assisted closed in-syringe extraction and derivatization for the determination of labile abietic acid and dehydroabietic acid in cosmetics.

J. Chromatogr. A. 1371 , 20-9, (2014)

Two resin acids, abietic acid (AA) and dehydroabietic acid (DHAA), in cosmetics may cause allergy or toxicoderma, but remain inaccurately investigated due to their lability. In this work, an accurate,...

Disproportionated rosin dehydroabietic acid in neoprene surgical gloves.

Dermatitis 21(3) , 157-9, (2010)

Allergic contact dermatitis (ACD) is a well-recognized immune-mediated disease often associated with the use of vulcanization accelerator-containing latex and nitrile gloves. Potential contact allerge...

Synthesis and antibacterial evaluation of New N-acylhydrazone derivatives from dehydroabietic acid.

Molecules 17(4) , 4634-50, (2012)

A series of new N-acylhydrazone derivatives were synthesized in good yields through the reactions of dehydroabietic acid hydrazide with a variety of substituted arylaldehydes. The structures of the sy...

 Synonyms

dehydroabietic acid
abietic acid, dehydro-
1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid
(+)-Dehydroabietic acid
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-
Abieta-8(14),9(11),12-trien-18-oic acid
Abieta-8,11,13-trien-18-oic acid,Dehydroabietate
EINECS 217-102-8
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