Licofelone

Modify Date: 2024-01-05 13:35:59

Licofelone structure	Common Name	Licofelone
	CAS Number	156897-06-2	Molecular Weight	379.879
	Density	1.2±0.1 g/cm3	Boiling Point	539.7±50.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₂ClNO₂	Melting Point	162-163ºC
	MSDS	N/A	Flash Point	280.2±30.1 °C

Use of Licofelone

Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor for the treatment of osteoarthritis. Licofelone (ML-3000) exerts anti-inflammatory and anti-proliferative effects. Licofelone (ML-3000) induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2].

Name	Licofelone
Synonym	More Synonyms

Description	Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor for the treatment of osteoarthritis. Licofelone (ML-3000) exerts anti-inflammatory and anti-proliferative effects. Licofelone (ML-3000) induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80. [2]. Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

References

[1]. Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.

[2]. Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.

Density	1.2±0.1 g/cm3
Boiling Point	539.7±50.0 °C at 760 mmHg
Melting Point	162-163ºC
Molecular Formula	C₂₃H₂₂ClNO₂
Molecular Weight	379.879
Flash Point	280.2±30.1 °C
Exact Mass	379.133911
PSA	42.23000
LogP	6.73
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.627
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY7759650

CHEMICAL NAME :: 1H-Pyrrolizine-5-acetic acid, 2,3-dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-

CAS REGISTRY NUMBER :: 156897-06-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H22-Cl-N-O2

MOLECULAR WEIGHT :: 379.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,159,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg/11D-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from duodenum

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1329,1994

Hazard Codes	Xi

Precursor 7
CAS#:79-37-8 Oxalyl chloride CAS#:133111-56-5 6-(4-CHLOROPHEN... CAS#:1061179-20-1 methyl 2-(6-(4-... CAS#:116673-95-1 5-Benzyl-3,3-di...
CAS#:1061179-22-3 2-(6-(4-chlorop... CAS#:536-38-9 2-Bromo-4'-chlo... CAS#:197963-31-8 2,2-dimethyl-7-...
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