SGC 0946
Modify Date: 2024-01-02 18:47:27
SGC 0946 structure
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Common Name | SGC 0946 | ||
|---|---|---|---|---|
| CAS Number | 1561178-17-3 | Molecular Weight | 618.566 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 771.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C28H40BrN7O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 420.4±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of SGC 0946SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.IC50 value: 0.3 nM(DOT1L) [1]Target: selective DOT1L inhibitorSGC 0946 is over 100-fold selective for other histone methyltransferases/HMTs. SGC 0946 potently reduces H3K79 dimethylation with IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells, which potently and selectively kills cells containing an MLL translocation. SGC 0946 is much more potent than its close analog EPZ004777, and serves as an excellent chemical probe for investigating DOT1L and further development of DOT1L inhibitors for cancer therapy. |
| Name | 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
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| Synonym | More Synonyms |
| Description | SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.IC50 value: 0.3 nM(DOT1L) [1]Target: selective DOT1L inhibitorSGC 0946 is over 100-fold selective for other histone methyltransferases/HMTs. SGC 0946 potently reduces H3K79 dimethylation with IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells, which potently and selectively kills cells containing an MLL translocation. SGC 0946 is much more potent than its close analog EPZ004777, and serves as an excellent chemical probe for investigating DOT1L and further development of DOT1L inhibitors for cancer therapy. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 771.5±60.0 °C at 760 mmHg |
| Molecular Formula | C28H40BrN7O4 |
| Molecular Weight | 618.566 |
| Flash Point | 420.4±32.9 °C |
| Exact Mass | 617.232483 |
| LogP | 4.72 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.662 |
| Storage condition | ?20°C |
| Water Solubility | DMSO: soluble20mg/mL, clear |
| 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]- |
| 5-Bromo-7-(5-deoxy-5-{isopropyl[3-({[4-(2-methyl-2-propanyl)phenyl]carbamoyl}amino)propyl]amino}-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| sgc 0946 |
| SGC0946 |