4-Hydroxyphenylacetic acid

Modify Date: 2024-01-02 10:00:09

4-Hydroxyphenylacetic acid structure	Common Name	4-Hydroxyphenylacetic acid
	CAS Number	156-38-7	Molecular Weight	152.147
	Density	1.3±0.1 g/cm3	Boiling Point	346.6±17.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₃	Melting Point	148-151 °C(lit.)
	MSDS	USA	Flash Point	177.6±17.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Hydroxyphenylacetic acid

4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

Name	4-hydroxyphenylacetic acid
Synonym	More Synonyms

Description	4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Phenols Research Areas >> Metabolic Disease
Target	Nrf2[1]
In Vivo	4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1[1].
References	[1]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653.

Density	1.3±0.1 g/cm3
Boiling Point	346.6±17.0 °C at 760 mmHg
Melting Point	148-151 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	177.6±17.4 °C
Exact Mass	152.047348
PSA	57.53000
LogP	0.77
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.596

4-Hydroxyphenylacetic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI2680000

CHEMICAL NAME :: Acetic acid, (p-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 156-38-7

BEILSTEIN REFERENCE NO. :: 1448766

LAST UPDATED :: 199803

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QV1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AI2680000
HS Code	2918290000

Precursor 10
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DownStream 9
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HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Prediction of skeletal muscle and fat mass in patients with advanced cancer using a metabolomic approach.

J. Nutr. 142(1) , 14-21, (2012)

Urine and plasma metabolites originate from endogenous metabolic pathways in different organs and exogenous sources (diet). Urine and plasma were obtained from advanced cancer patients and investigate...

4-Hydroxyphenyl acetic acid

2-(4-Hydroxyphenyl)acetic acid

4-hydroxyphenylacetic acid

(p-hydroxyphenyl)-Acetic acid

(4-Hydroxy-phenyl)-acetic acid

4-Hydroxy-Benzeneacetic acid

(4-Hydroxyphenyl)acetic acid

MFCD00004347

Benzeneacetic acid, 4-hydroxy-

EINECS 205-851-3

PHPA

BioBioPha
China
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Hydroxyphenylacetic acid
Price: ￥198.0/20mg ￥478.0/500g ￥128.0/100g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxyphenylacetic acid
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Hydroxyphenylacetic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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4-Hydroxyphenylacetic acid

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