PFE-360

Modify Date: 2024-01-10 16:55:40

PFE-360 structure	Common Name	PFE-360
	CAS Number	1527475-61-1	Molecular Weight	308.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₆N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PFE-360

PFE-360 is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].

Name	PFE-360

Description	PFE-360 is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].
Related Catalog	Signaling Pathways >> Autophagy >> LRRK2 Research Areas >> Neurological Disease
Target	IC50: 2.3 nM (LRRK2 in vivo) [1][2].
References	[1]. Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences. [2]. Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27.

Molecular Formula	C₁₆H₁₆N₆O
Molecular Weight	308.34
Storage condition	2-8°C

DC Chemicals Limited
China
Product Name: PFE-360
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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