2-Chloroadenosine

Modify Date: 2024-01-02 18:22:27

2-Chloroadenosine structure	Common Name	2-Chloroadenosine
	CAS Number	146-77-0	Molecular Weight	301.686
	Density	2.2±0.1 g/cm3	Boiling Point	643.3±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂ClN₅O₄	Melting Point	162 °C
	MSDS	Chinese USA	Flash Point	342.8±34.3 °C

Use of 2-Chloroadenosine

2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].

Name	2-Chloroadenosine
Synonym	More Synonyms

Description	2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41. [2]. Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41.

[2]. Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92.

Density	2.2±0.1 g/cm3
Boiling Point	643.3±65.0 °C at 760 mmHg
Melting Point	162 °C
Molecular Formula	C₁₀H₁₂ClN₅O₄
Molecular Weight	301.686
Flash Point	342.8±34.3 °C
Exact Mass	301.057770
PSA	139.54000
LogP	-0.46
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.912
Water Solubility	H2O: 10 mg/mL, clear, colorless

2-Chloroadenosine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7357550

CHEMICAL NAME :: Adenosine, 2-chloro-

CAS REGISTRY NUMBER :: 146-77-0

BEILSTEIN REFERENCE NO. :: 0043957

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H12-Cl-N5-O4

MOLECULAR WEIGHT :: 301.72

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ GG IZ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 118,95,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 118,95,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 603 ug/kg

SEX/DURATION :: female 11-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),35A,1982

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7357550

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6-Amino-2-chloro-9-(β-D-ribofuranosyl)purine Hydrate

2-CADO,6-Amino-2-chloropurine riboside

2-Chloroadenosine

6-Amino-2-chloropurine Riboside Hydrate

2-CADO Hydrate

EINECS 205-678-3

(2R,3R,4S,5R)-2-(6-Amino-2-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol

MFCD00005734

Adenosine, 2-chloro-

2-Chlor-9-(β-D-ribofuranosyl)-9H-purin-6-amin

6-Amino-2-Chloropurine Riboside

2-chloro adenosine

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Chloroadenosine
Price: ￥148.0/1g ￥468.0/5g
Purity: 97.0%
Stocking Period: 2 Day
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DC Chemicals Limited
China
Product Name: 2-Chloroadenosine
Price:
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Chloroadenosine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
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2-Chloroadenosine

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