Nequinate

Modify Date: 2024-01-04 13:49:55

Nequinate structure	Common Name	Nequinate
	CAS Number	13997-19-8	Molecular Weight	365.422
	Density	1.2±0.1 g/cm3	Boiling Point	520.7±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₃NO₄	Melting Point	287.5ºC
	MSDS	Chinese USA	Flash Point	268.7±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Nequinate

Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].

Name	Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
Synonym	More Synonyms

Description	Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].
Related Catalog	Research Areas >> Infection Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
In Vitro	Xanthine oxidase (XOD) is a successful and safe drug target for lowering lower serum urate (sUA) levels , it plays an important role in the catabolism of purine Nequinate shows an inhibition of 12.0% to inhibit XOD activities[2].
References	[1]. D K McLoughlin, et al.Efficacy of Nequinate Against Thirteen Strains of Eimeria Tenella and the Development of a Nequinate-Resistant Strain.Avian Dis. Oct-Dec 1973;17(4):717-21. [2]. Yanfen Niu, et al. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. J Pharmacol Sci. 2017 Nov;135(3):114-120.

Density	1.2±0.1 g/cm3
Boiling Point	520.7±50.0 °C at 760 mmHg
Melting Point	287.5ºC
Molecular Formula	C₂₂H₂₃NO₄
Molecular Weight	365.422
Flash Point	268.7±30.1 °C
Exact Mass	365.162720
PSA	68.39000
LogP	6.01
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.579

Nequinate MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H413
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
RIDADR	NONH for all modes of transport
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.

Vet. Parasitol. 76(3) , 163-71, (1998)

Coccidia were isolated from a commercial broiler farm with a history of suspected drug resistance. The sensitivity profiles of the Eimeria spp. isolates against the anticoccidial drugs nicarbazin (NIC...

Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken.

Res. Vet. Sci. 47(1) , 125-8, (1989)

Thirty isolates of Eimeria tenella obtained from broiler and breeder farms were examined for their sensitivity to anticoccidial drugs. All were sensitive to robenidine, 28 were sensitive to methyl ben...

Immunity and effect of clopidol/methyl benzoquate and robenidine before and after weaning on rabbit coccidiosis in the field.

Res. Vet. Sci. 35(2) , 211-6, (1983)

For 15 months the anticoccidial effect of 200 ppm clopidol/methyl benzoquate and of 50 ppm robenidine, and the development of immunity against five different species of Eimeria were followed in a clos...

7-(Benzyloxy)-6-n-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Methyl Ester

7-(Benzyloxy)-6-n-butyl-3-methoxycarbonyl-4-quinolone

nequinate

MFCD00867198

methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate

EINECS 237-796-6

3-Quinolinecarboxylic acid, 6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-, methyl ester

7-(Benzyloxy)-6-n-butyl-4-hydroxy-3-quinolinecarboxylic Acid Methyl Ester

3-Methoxycarbonyl-6-n-butyl-7-benzyloxy-4-oxoquinoline

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Nequinate
Price: ￥2808.0/10mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Nequinate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM - Nequinate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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