Duramycin

Modify Date: 2024-01-06 13:09:10

Duramycin structure	Common Name	Duramycin
	CAS Number	1391-36-2	Molecular Weight	1999.25000
	Density	1.0238 (rough estimate)	Boiling Point	N/A
	Molecular Formula	C₈₉H₁₂₅N₂₃O₂₅S₃	Melting Point	271-273ºC
	MSDS	Chinese USA	Flash Point	N/A

Use of Duramycin

Duramycin (Moli1901;Lancovutide) is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin stimulates chloride secretion in airway epithelium and has the potential for cystic fibrosis treatment. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects[1][2].

Name	Duramycin
Synonym	More Synonyms

Description	Duramycin (Moli1901;Lancovutide) is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin stimulates chloride secretion in airway epithelium and has the potential for cystic fibrosis treatment. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Duramycin does stimulate Cl- efflux from cystic fibrosis bronchial epithelial cells (CFBE) in a narrow concentration range (around 1 μM). However, 100 and 250 μM of Duramycin inhibits Cl- efflux from CFBE cells. The [Ca2+]i is increased by 3 μM Duramycin in 16HBE cells, but decreases after 1, and 3 μM of Duramycin in CFBE cells[1]. Duramycin affects protein-lipid interactions, impairs protein translocation, induces aggregation of lipid vesicles, and inhibits ATP-dependent Ca2+ uptake by the sarcoplasmic reticulum[1].
In Vivo	Evaluation of [68Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [68Ga]NODAGA-Duramycin. [68Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice[3].
References	[1]. Oliynyk I, et al. Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non-cystic fibrosis epithelia. APMIS. 2010 Dec;118(12):982-90. [2]. Huo L, et al. Insights into the Biosynthesis of Duramycin. Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02698-16. [3]. Rix A, et al. Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin. Mol Imaging Biol. 2019 Aug 8.

Density	1.0238 (rough estimate)
Melting Point	271-273ºC
Molecular Formula	C₈₉H₁₂₅N₂₃O₂₅S₃
Molecular Weight	1999.25000
Exact Mass	1997.82000
PSA	835.99000
Index of Refraction	1.6680 (estimate)
Storage condition	2-8°C
Water Solubility	0.1 M HCl: soluble10mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV7100000

CHEMICAL NAME :: Ancovenin, 2-L-lysine-6-(3-aminoalanine)-10-L-phenylalanine-12-L -phenylalanine-13-L-v aline- 15-(erythro-3-hydroxy-L-aspartic acid)-, cyclic 6-19)-imine

CAS REGISTRY NUMBER :: 1391-36-2

LAST UPDATED :: 199801

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C89-H125-N23-O25-S3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 17,262,1964

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	BV7100000

Stimulation of sodium transport by duramycin in cultured human colonic epithelia.

J. Pharmacol. Exp. Ther. 259 , 1050, (1991)

Effects of two peptide antibiotics, duramycin and Ro 09-0198, on ion transport in cultured human colonic epithelia were investigated. Both peptides acted on the apical face of epithelial monolayers, c...

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.

EMBO J. 31 , 4106-23, (2012)

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalyti...

Phosphatidylethanolamine is externalized at the surface of microparticles.

Biochim. Biophys. Acta 1821(12) , 1501-7, (2012)

Microparticles (MPs) are membrane-bound vesicles shed normally or as a result of various (pathological) stimuli. MPs contain a wealth of bio-active macromolecules. Aminophospholipid phosphatidylserine...

UNII-BPR0F3X56H

Lancovutide [INN]

Ancovenin,2-L-lysine-6-(3-aminoalanine)-10-L-phenylalanine-12-L-phenylalanine-13-L-valine-15-(erythro-3-hydroxy-L-aspartic acid)-,cyclic 6-19)-imine

Leucopeptin

LANCOVUTIDE

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Duramycin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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