UNC0631
Modify Date: 2024-01-02 17:19:11
UNC0631 structure
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Common Name | UNC0631 | ||
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| CAS Number | 1320288-19-4 | Molecular Weight | 635.926 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 763.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C37H61N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 415.5±35.7 °C | |
Use of UNC0631UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM.IC50 value: 4 nM [1]Target: G9aUNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231 cells and had low cell toxicity. In particular, compounds 7 was more potent than compound 5 and had a similar tox/function ratio in MDAMB-231 cells. UNC 0631 showed excellent separation of functional potency versus cell toxicity in MDA-MB-231 cells, thecompound was further evaluated in a variety of cell lines to characterize it's cellular potency and cell toxicity. UNC 0631 had excellent tox/functionratios in these cell lines. |
| Name | N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine |
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| Synonym | More Synonyms |
| Description | UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM.IC50 value: 4 nM [1]Target: G9aUNC 0631, which had high in vitro potency versus G9a and improved lipophilicity, was highly potent (IC50 < 0.06 μM) in reducing H3K9me2 levels in MDA-MB-231 cells and had low cell toxicity. In particular, compounds 7 was more potent than compound 5 and had a similar tox/function ratio in MDAMB-231 cells. UNC 0631 showed excellent separation of functional potency versus cell toxicity in MDA-MB-231 cells, thecompound was further evaluated in a variety of cell lines to characterize it's cellular potency and cell toxicity. UNC 0631 had excellent tox/functionratios in these cell lines. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 763.4±70.0 °C at 760 mmHg |
| Molecular Formula | C37H61N7O2 |
| Molecular Weight | 635.926 |
| Flash Point | 415.5±35.7 °C |
| Exact Mass | 635.488647 |
| PSA | 72.46000 |
| LogP | 6.29 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.579 |
| Storage condition | 2-8℃ |
| N-(1-(benzo[d][1,3]dioxol-5-yl)propyl)-4-methylbenzenesulfonamide |
| N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine |
| Benzenesulfonamide,N-[1-(1,3-benzodioxol-5-yl)propyl]-4-methyl |
| UNC0631 |
| UNC 0631 |